Journal Club with Dr. Jonathan Cachat – Page 3

Journal Club #21: Heroin to Buprenorphine to Kratom in Appalachia

Journal Club with Dr. Jonathan Cachat

Journal Club #21: Heroin to Buprenorphine to Kratom in Appalachia

00:00 / 47:25

Study examined in this episode: Smith, K. E., Bunting, A. M., Walker, R., Hall, M. T., Grundmann, O., & Castillo, O. (2019). Non-Prescribed Buprenorphine Use Mediates the Relationship between Heroin Use and Kratom Use among a Sample of Polysubstance Users. Journal of psychoactive drugs, 51(4), 311–322. https://doi.org/10.1080/02791072.2019.1597224Pubmed link https://pubmed.ncbi.nlm.nih.gov/30961450/ Link to all studies covered on …

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Journal Club #20: Cholesterol Study on Kratom Users in Thailand

Journal Club with Dr. Jonathan Cachat

Journal Club #20: Cholesterol Study on Kratom Users in Thailand

00:00 / 35:57

A new study from Thailand (La-up, 2021) found traditional users of kratom had elevated levels of high-density lipoprotein (HDL or “good” cholesterol) and low levels of triglycerides. In the largest recent study of its kind, researchers recruited 581 participants, half kratom consumers, and half who did not consume kratom as a control group. Though the …

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Journal Club #19: The FDA’s Bad Science on Kratom

Journal Club with Dr. Jonathan Cachat

Journal Club #19: The FDA's Bad Science on Kratom

00:00 / 49:47

Neuroscientist Dr. Jonathan Cachat and host Brian Gallagher look at the blistering report by Jane Babin released in August 2018: “FDA Fails to Follow the Science on Kratom” (PDF available here https://t.co/G76TVsWdLY?amp=1 ). Babin demonstrates how FDA manipulated data to create a Schedule I justification based on what a former HHS Assistant Secretary of Health …

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Journal Club #18: Pineal Gland and DMT Facts and Myth

Journal Club with Dr. Jonathan Cachat

Journal Club #18: Pineal Gland and DMT Facts and Myth

00:00 / 39:53

In a departure from kratom science, Dr. Cachat and Brian look at a paper by a pioneering pharmacologist and researcher in the field of psychedelics, Dr. David E. Nichols. Dr. Nichols methodically lays out his case for why endogenous DMT produced in the pineal gland, brain, or other parts of the human body is not …

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Journal Club #17: Psychoactive plants in your backyard and around the world

Journal Club with Dr. Jonathan Cachat

Journal Club #17: Psychoactive plants in your backyard and around the world

00:00 / 57:55

The subject of episode 17 of Kratom Science Journal Club Dr. Jon Cachat and Brian Gallagher talk about an article from Portuguese scientists about “new” psychoactive substances of natural origin, some of which have been consumed responsibly for centuries, some of which are best used if you want to murder someone via poisoning them. Oh, …

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Journal Club #16: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract

Journal Club with Dr. Jonathan Cachat

Journal Club #16: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract

00:00 / 47:20

Another study from University of Florida is the “first report that has simultaneously evaluated the systemic exposure of 11 kratom alkaloids following the administration of traditional and commercial kratom products” (Kamble, 2021). Researchers looked at the pharmacokinectics (how drugs move through the body and are metabolized) of alkaloids in rat plasma following the oral administration …

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Journal Club #15, Q&A Part 2: Kratom Legality, Kratom and Pharma, Dopamine Agonists, Libido, and Random Effects

Journal Club with Dr. Jonathan Cachat

Journal Club #15, Q&A Part 2: Kratom Legality, Kratom and Pharma, Dopamine Agonists, Libido, and Random Effects

00:00 / 33:27

Note: Nothing in this podcast or on KratomScience.com is intended to be medical advice, nor should it be taken as such. We’re not medical doctors. Please don’t listen to podcasts for advice on what you should or should not put in your body. Dr. Cachat continues answering questions from February’s r/kratom Ask Me Anything. This …

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Journal Club #14, Q&A Part 1: Kratom and Liver Enzymes, Alcohol, Pain Management, and Serotonin

Journal Club with Dr. Jonathan Cachat

Journal Club #14, Q&A Part 1: Kratom and Liver Enzymes, Alcohol, Pain Management, and Serotonin

00:00 / 34:05

Note: Nothing in this podcast or on KratomScience.com is intended to be medical advice, nor should it be taken as such. We’re not medical doctors. Please don’t listen to podcasts for advice on what you should or should not put in your body. For episode #14, Dr. Jonathan Cachat answers half of the remaining question …

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Journal Club #13: How Kratom Alkaloids Act on Brain Receptors

Journal Club with Dr. Jonathan Cachat

Journal Club #13: How Kratom Alkaloids Act on Brain Receptors

00:00 / 39:13

We all know the mitragynine and 7-hydroxymitraginine act on the mu-opioid receptor. But for episode #13 of Journal Club we talk about a study that looks closely at the binding affinity of various kratom alkaloids on the plethora of opioid and adrenergic receptors in the brain. How exactly does this work? How do different alkaloids …

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Journal Club #12: Kratom Cultivation Studied

Journal Club with Dr. Jonathan Cachat

Journal Club #12: Kratom Cultivation Studied

00:00 / 33:58

This time Dr. Jonathan Cachat and I look at a study where a team from University of Florida cultivated 68 kratom trees in a greenhouse, gave them varying levels of fertilizer, and measured for biomass, chlorophyll, and alkaloid content. Dr. Jon talks about similar studies he did with cannabis, and we go into what that …

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