Series: Journal Club with Dr. Jonathan Cachat

Dr. Jonathan Cachat joins Kratom Science Podcast host Brian Gallagher to talk about kratom research. Each episode we pick a study about kratom published in a peer-reviewed journal.

Journal Club #32: Cannabis Strains, Cannabinoids, and Terpenes

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #32: Cannabis Strains, Cannabinoids, and Terpenes
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Today on Journal Club, Dr. Jon Cachat look at a study in 2021 out of University of Colorado, Boulder in cooperation with Leafly that examines nearly 90,000 cannabis samples. Does Indica, Sativa, and Hybrid really mean anything in terms of psychoactive effects? Are cannabis strains labelled consistently in terms of cannabinoid and terpene content? We …

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Journal Club #31: A Kratom Guide for Healthcare Providers

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #31: A Kratom Guide for Healthcare Providers
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Perhaps the most important paper Dr. Jon and Brian have covered so far, “Understanding Kratom: A Guide for Healthcare Providers” is a comprehensive introduction to kratom for those who provide direct care to kratom consumers, such as physicians or mental health specialists. In this paper spearheaded by past Kratom Science Podcast guest, Dr. Marc Swogger, …

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Journal Club #30: Can Light Therapy Relieve Opioid Craving?

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #30: Can Light Therapy Relieve Opioid Craving?
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This week we look at very interesting study led by Fredric Schiffer based on this theory of Dual Brain Psychology (DBP). DBP “posits that one brain hemisphere tends to be relatively mature and healthy, while the other hemisphere may be more affected by past traumas and supports a personality that is more prone to immature …

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**REPOST*** Journal Club #29: Kratom Toxicity and Medicolegal Issues, Cannabis Museum

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
**REPOST*** Journal Club #29: Kratom Toxicity and Medicolegal Issues, Cannabis Museum
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REPOST info: Yesterday I accidentally posted last week’s episode with this week’s information. I corrected this mistake 45 minutes after posting. Since the change is reflected on some listening apps and not others, I’m posting the episode again. Sorry! For #29 of Kratom Science Journal Club, JC and Brian look at a 2019 report on …

**REPOST*** Journal Club #29: Kratom Toxicity and Medicolegal Issues, Cannabis Museum Read More »

Journal Club #29: Kratom Toxicity and Medicolegal Issues, and the Cannabis Museum

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #29: Kratom Toxicity and Medicolegal Issues, and the Cannabis Museum
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For #29 of Kratom Science Journal Club, JC and Brian look at a 2019 report on toxicological events having to do with mitragynine. Does mitragynine increase the effects of other drugs? How toxic is kratom on its own? Other alkaloids have commonly been counted as mitragynine, so what are the ramifications? All this and other …

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Journal Club #28: Mitragynine Does Not Rely on 7-hydroxymitragynine for Pain Relief Effects

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #28: Mitragynine Does Not Rely on 7-hydroxymitragynine for Pain Relief Effects
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Dr. Cachat and host Brian Gallagher look at a groundbreaking study from University of Florida School of Pharmacy showing mitragynine has pain relieving effects independent of its metabolism into 7-hydroxymitragynine. This could be revolutionary in the study of kratom as a safer pain medicine. We go on to talk about the cannabis testing lab that …

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Journal Club #27: Does Kratom Kill…E-coli and Streptococcus Pneumoniae?

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #27: Does Kratom Kill...E-coli and Streptococcus Pneumoniae?
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Spoiler alert: kinda, but its more the quercetin in kratom, which is available in many food plants and as a dietary supplement on its own. This study comes to us from a team at Universitas Nahdlatul Ulama Surabaya (UNUSA) in Surabaya, Indonesia, on the island of Java, south of the island of Kalimantan, where most …

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Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice
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Dr. JC and Brian look at a study out of University of Science, Malaysia. The comprehensive and detailed study in mice from University of Science, Malaysia revealed mitragynine in very high doses is an agonist (binds to and activates) cannabinoid receptor Type 1 (CB1). Mice administered with high-dose mitragynine demonstrated similar reward-seeking behavior and cognitive …

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Journal Club #25: Dopamine Response to Mitragynine in Rats

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #25: Dopamine Response to Mitragynine in Rats
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Dr. Jon Cachat and host Brian Gallagher look at a study that examined dopamine levels with an electrochemical sensor in rats administered with various levels of mitragynine. Dopamine release was detected as significant levels after a high dose of mitragynine after 4 days. Questions explored in this episode include: Does this accurately measure the kratom …

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Journal Club #24: Kratom-Induced Psychosis? A Case Report

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #24: Kratom-Induced Psychosis? A Case Report
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Dr. Jonathan Cachat and host Brian Gallagher look at a case report of a supposed kratom-induced psychosis out of a student team from West Virginia University School of Medicine Department of Psychiatry, advised by MDs Alexander Muacevic and John R Adler. A 43 year old man combat veteran with six tours of duty, traumatic brain …

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