Podcast: Journal Club with Dr. Jonathan Cachat

Dr. Jonathan Cachat joins Kratom Science Podcast host Brian Gallagher to talk about kratom research. Each episode we pick a study about kratom published in a peer-reviewed journal.

Journal Club #36: Mitragynine for Chemotherapy-Induced Pain

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #36: Mitragynine for Chemotherapy-Induced Pain
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Dr. Jon and Brian look at a study (Farkas et al., 2022 https://doi.org/10.1016/j.ibneur.2022.08.007) in mice out of Temple University exploring whether mitragynine can help attenuate chemotherapy-induced peripheral neuropathic (CIPN). The team used oxaliplatin, a chemotherapy drug, to induce this condition in an equal number of male and female mice. Mitragynine was also combined with four …

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Journal Club #35: Feeding Kratom to Goats

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #35: Feeding Kratom to Goats
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Dr. Jon and Brian explore a study out of Thailand where goats meat goats ate feed supplemented with dried kratom leaves. What effect did this have on the goats body weight, cholesterol, blood, and feed conversion ratio? Even if it does work, will farmers be able to afford kratom as a feed supplement, given the …

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Journal Club #34: How to Change Your Mind Documentary

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #34: How to Change Your Mind Documentary
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Dr. Jon and Brian take a break from kratom to look at the recently released Netflix documentary series hosted by Michael Pollan, How to Change Your Mind. In related good news: the DEA backed off its decision to schedule five psychedelics. Hamilton Morris tweets. “Today the DEA withdrew their plan to prohibit DiPT, 4-HO-DiPT, 5-MeO-MiPT, …

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Journal Club #33: Kratom Scientists Pen Letter Questioning Case Report Review

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #33: Kratom Scientists Pen Letter Questioning Case Report Review
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Dr. Cachat and Brian look at a letter (Smith et al, 2022) authored by former Kratom Science Podcast guests Dr. Kirsten Smith, Dr. Oliver Grundmann, Dr. Chris McCurdy, Dr. Darshan Singh, and other experts in the kratom field. The letter questions a systematic review (Broyan et al, 2022) of kratom case reports that offers buprenorphine …

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Journal Club #32: Cannabis Strains, Cannabinoids, and Terpenes

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #32: Cannabis Strains, Cannabinoids, and Terpenes
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Today on Journal Club, Dr. Jon Cachat look at a study in 2021 out of University of Colorado, Boulder in cooperation with Leafly that examines nearly 90,000 cannabis samples. Does Indica, Sativa, and Hybrid really mean anything in terms of psychoactive effects? Are cannabis strains labelled consistently in terms of cannabinoid and terpene content? We …

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Journal Club #31: A Kratom Guide for Healthcare Providers

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #31: A Kratom Guide for Healthcare Providers
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Perhaps the most important paper Dr. Jon and Brian have covered so far, “Understanding Kratom: A Guide for Healthcare Providers” is a comprehensive introduction to kratom for those who provide direct care to kratom consumers, such as physicians or mental health specialists. In this paper spearheaded by past Kratom Science Podcast guest, Dr. Marc Swogger, …

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Journal Club #30: Can Light Therapy Relieve Opioid Craving?

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #30: Can Light Therapy Relieve Opioid Craving?
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This week we look at very interesting study led by Fredric Schiffer based on this theory of Dual Brain Psychology (DBP). DBP “posits that one brain hemisphere tends to be relatively mature and healthy, while the other hemisphere may be more affected by past traumas and supports a personality that is more prone to immature …

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**REPOST*** Journal Club #29: Kratom Toxicity and Medicolegal Issues, Cannabis Museum

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
**REPOST*** Journal Club #29: Kratom Toxicity and Medicolegal Issues, Cannabis Museum
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REPOST info: Yesterday I accidentally posted last week’s episode with this week’s information. I corrected this mistake 45 minutes after posting. Since the change is reflected on some listening apps and not others, I’m posting the episode again. Sorry! For #29 of Kratom Science Journal Club, JC and Brian look at a 2019 report on …

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Journal Club #29: Kratom Toxicity and Medicolegal Issues, and the Cannabis Museum

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #29: Kratom Toxicity and Medicolegal Issues, and the Cannabis Museum
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For #29 of Kratom Science Journal Club, JC and Brian look at a 2019 report on toxicological events having to do with mitragynine. Does mitragynine increase the effects of other drugs? How toxic is kratom on its own? Other alkaloids have commonly been counted as mitragynine, so what are the ramifications? All this and other …

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Journal Club #28: Mitragynine Does Not Rely on 7-hydroxymitragynine for Pain Relief Effects

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #28: Mitragynine Does Not Rely on 7-hydroxymitragynine for Pain Relief Effects
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Dr. Cachat and host Brian Gallagher look at a groundbreaking study from University of Florida School of Pharmacy showing mitragynine has pain relieving effects independent of its metabolism into 7-hydroxymitragynine. This could be revolutionary in the study of kratom as a safer pain medicine. We go on to talk about the cannabis testing lab that …

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