Journal Club #33: Kratom Scientists Pen Letter Questioning Case Report Review

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #33: Kratom Scientists Pen Letter Questioning Case Report Review

Dr. Cachat and Brian look at a letter (Smith et al, 2022) authored by former Kratom Science Podcast guests Dr. Kirsten Smith, Dr. Oliver Grundmann, Dr. Chris McCurdy, Dr. Darshan Singh, and other experts in the kratom field. The letter questions a systematic review (Broyan et al, 2022) of kratom case reports that offers buprenorphine as a solution to “kratom use disorder”. Kratom-related case reports typically originate with patients showing up to emergency rooms and physicians’ offices with symptoms. In these case reports, kratom product samples are rarely if ever tested for adulterants or contamination. The strength of the kratom product and dose levels seem to nearly always go unreported or wildly misreported (for example, the Broyan et al. review the Smith et al. letter addresses here claims the patients consumed an average of 92 grams of kratom per day). Furthermore, history or current use of other drugs is often overlooked.

Dr. Jon also talks about his trouble getting public data on cannabis testing and use trends from the State of Ohio’s Marijuana Enforcement Tracking Reporting & Compliance (METRC) program.


  • Broyan, V. R., Brar, J. K., Allgaier Student, T., & Allgaier, J. T. (2022). Long-term buprenorphine treatment for kratom use disorder: A case series. Substance abuse, 43(1), 763–766.
  • Smith, K. E., Dunn, K. E., Epstein, D. H., Feldman, J. D., Garcia-Romeu, A., Grundmann, O., Henningfield, J. E., McCurdy, C. R., Rogers, J. M., Schriefer, D., Singh, D., & Weiss, S. T. (2022). Need for clarity and context in case reports on kratom use, assessment, and intervention. Substance abuse, 43(1), 1221–1224.

Dr. Jonathan Cachat is on social media @jcachat and
Kratom Science is on and Twitter @kratomscience
Music: Captain Bigwheel “Moonrunner”
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1 thought on “Journal Club #33: Kratom Scientists Pen Letter Questioning Case Report Review”

  1. Governor Gavin Newsome “Every overdose death is preventable,” said Sen. Wiener. “We have the tools to end these deaths, get people healthy, and reduce harm for people who use drugs. Right now, we are letting people die on our streets for no reason other than an arbitrary legal prohibition that we need to remove. SB 57 is long overdue and will make a huge impact for some of the most vulnerable people in our community.” Much in line with your article. Kudos to all the hard work of fellow Kratom warriors.

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