Kratom Science

Your Resource Center For Kratom Research


kratom-leafs 2Mitragyna speciosa (ketum, kratom or kratum, Thai: กระท่อม) is a tropical deciduous and evergreen tree in the coffee family (Rubiaceae) native to Southeast Asia in the Indochina and Malesia floristic regions. Its leaves are used for medicinal properties. It is psychoactive, and leaves are chewed to uplift mood and to treat health problems.

M. speciosa is indigenous to Thailand and, despite growing naturally in the country, has been outlawed for 70 years and was originally banned because it was reducing the Thai government’s tax revenue from opium distribution.


Follow any of the links below to learn more about the history and research behind kratom:

Earth Plant 2
Ethnopharmacology Of Kratom And The Mitragyna Alkaloids
Department of Anatomy, University of Auckland Medical School, Private Bag, Aucklund (New Zealand)

Mitragyna speciosa Korth. (“kratom”, “biak”) is a Southeast Asian tree, the leaves of which provide several alkaloids of considerable interest and seemingly contradictory properties. The first formal pharmacological investigations were carried out at the University of Cambridge. Grewal performed a series of experiments on animal tissues and found mitragynine to be a central nervous system stimulant rather than depressant.
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⇒ Pharmacology Of Kratom: An Emerging Botanical Agent With Stimulant, Analgesic And Opioid-Like Effects
Prozialeck WC, Jivan JK, Andurkar SV
Department of Pharmacology, Midwestern University/Chicago College of Osteopathic Medicine

Kratom leaves produce complex stimulant and opioid-like analgesic effects. In Asia, kratom has been used to stave off fatigue and to manage pain, diarrhea, cough, and opioid withdrawal. Recently, kratom has become widely available in the United States and Europe by means of smoke shops and the Internet. Analyses of the medical literature and select Internet sites indicate that individuals in the United States are increasingly using kratom for the self-management of pain and opioid withdrawal. Kratom contains pharmacologically active constituents, most notably mitragynine and 7-hydroxymitragynine.
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⇒ Self-Treatment Of Opioid Withdrawal Using Kratom (Mitragynia Speciosa Korth)
Edward W. Boyer, Kavita M. Babu, Jessica E. Adkins, Christopher R. McCurdy, and John H. Halpern
University of Massachusetts Medical School, Harvard Medical School, University of Mississippi

We report the self-treatment of chronic pain and opioid withdrawal with kratom. The predominant alkaloid of kratom, mitragynine, binds mu- and kappa-opioid receptors, but has additional receptor affinities that might augment its effectiveness at mitigating opioid withdrawal. The natural history of kratom use, including its clinical pharmacology and toxicology, are poorly understood.
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8 thoughts on “Kratom Science

  1. Hi there. I’m a somewhat desperate mother. My son is a division I college diver and has been diagosed with a bilateral L5 pars defect with moderate L5-S1 disc degeneration. He has stopped diving (too painful). Even with halting his sport he experiences daily chronic pain. Sitting in class is painful, walking is painful. Does anyone know what the best strain of kratom I should give him? Thanks in advance for any help you can provide. Kathleen

    1. any red strain helps my chronic pain and cures my depression, i think that would work best for him.

  2. i get headaches from coffee so im looking for an alternative. As a 4th year med student cramming for the boards and working long hours what might be a recommended strain/dose ? thanks

  3. I have purchased this but unsure of amount to use I have a very low tolerance to drugs so I am abit scared to use it,i am in chronic pain everyday suffer with fibromyalgia 7 nerve damage

    1. Hi, Lee-Ann!
      I am an RN and I also have FM and spinal stenosis. I had a 4 vertebrae in my neck fused in 2010 which helped with the arm numbness but not the pain. Over a year ago I went to my doc with severe pain in my right arm. He spent the entire 15 minute visit making me fill out my state’s 5 page Controlled Drug Contract (all patients seeking pain relief must sign this unless they have stage 4 cancer) then ordered an x-ray of my shoulder to rule out rotator cuff injury – it was negative. After begging he gave me an Rx for an opiate – LOL! – it was a pediatric dose and the pharmacy didn’t carry it.

      You asked your question 2 months ago so I hope you already have an answer. If not, here’s my experience with “K”. The strain I chose, after tons of research, was Premier Shiva Maeng Da powder for its analgesic and energizing properties. I started out mixing 1 tsp with grapefruit juice (the juice makes it work longer) and am now at 1 Tbsp (about 7 grams) and am happy with the results. “K” doses are self-limiting because it will make you nauseated at higher does but I experienced that just once. Sometimes after a few hours I get drowsy. Warning: never drive after taking “K”! Good luck treating your fibromyalgia – we “Fummers” have to support each other!

      1. Hi Fellow FMers! You are just who I am looking for and I just brought up the website. I’m 70 years old and have had inherited FM all my life – gym class was a nightmare!. Mom was diagnosed with MS in 1945 while pregnant w/me but I have a feeling the pregnancy just worsened an existing condition because she had once said she was a “sickly child”. She wasn’t given the proper diagnosis of FM until her 50’s. I got mine at 32. My daughter, now 45, started showing signs at 15 and she’s in horrible shape and on Vicodin for years now. As soon as I try this out I’m going to tell her about it, and the benefit of getting off the Vicoden will be very helpful.

        I also was told 15 years ago that I have a disintegrating disc below my lumber spine. I’ve learned to work with the FM and pay the price for a few days or longer (the profound fatigue is what lays me the lowest) but the back pain radiating to my right hip with what feels like a javalin stuck right in between spine and hip joint is what interferes with the heavy duty home maintenance and repair I have to do, i.e. tear off leaking addition roof and replace before bathroom ceiling drywall falls down. Once I start I have to keep going and get it done. I’m counting on Kratom pulling me through it. I should have found this forum last night but what I found was a Zen type of site that sells all the things their rituals use but also alternative medicine botanicals. I did learn a lot about the Kratom, including dosages, types, preparations and went ahead and ordered 2 oz of a Bali white vein crushed leaf. I had learned the red is best but it was too expensive for an experiment – social security, you know. Now I read a recipe here that is so much simpler than what I read last night and calls for powder. Sigh. . . I can’t type anymore now; about an hour ago I had to break up a fight between my 2 Miniature Schnauzer studs who hate each other and got a deep bite to the base of my thumb. . . I have a feeling I’m going to wish I already had that Kratom!! It is really starting to hurt!

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