Do you take kratom for ADHD ?
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Do you take kratom for ADHD ?

Do you have attention deficit hyperactivity disorder (ADHD) and consume kratom? Or have you tried kratom for ADHD symptoms or side effects of medications? How did it make you feel?…

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Is Kratom a Drug?
1950s ad for methedrine, aka legal methamphetamine

Is Kratom a Drug?

Is kratom a drug, a medicinal herb, a dietary supplement, a "safe food", a tea? These terms have a whole lot to do with social perception, a little to do…

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Toxic Levels of Kratom and LD50 of Mitragynine
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Toxic Levels of Kratom and LD50 of Mitragynine

Mitragynine is the most abundant alkaloid in kratom. Kratom contains about 40 alkaloids that we know of. All of the alkaloids combined make up only 0.5-1.5% of the total leaf…

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Study shows mitragynine metabolizes into 7-Hydroxymitragynine
Illustration from Kruegel study of MG being metabolized into 7OH before acting on the MOR to produce pain relieving effects

Study shows mitragynine metabolizes into 7-Hydroxymitragynine

Citation Kruegel AC, Uprety R, Grinnell SG, et al. 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects. ACS Cent Sci. 2019;5(6):992-1001. doi:10.1021/acscentsci.9b00141 Summary…

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Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine
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Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine

Article Citation with Link to Full Text Harun N, Johari IS, Mansor SM, Shoaib M. Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats. Psychopharmacology (Berl).…

Continue Reading Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine