Research

List of “New” Psychoactive Substances of Natural Origin

Note: This article is a summary of the journal article cited as follows:Gonçalves, J., Luís, Â., Gallardo, E., & Duarte, A. P. (2021). Psychoactive Substances of Natural Origin: Toxicological Aspects, Therapeutic Properties and Analysis in Biological Samples. Molecules (Basel, Switzerland), 26(5), 1397. https://doi.org/10.3390/molecules26051397Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961374/ Scientists from Portugal, where the possession and consumption of all …

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Teenager Attempts Suicide by Swallowing 45 Kratom Capsules

In a 2020 case report, a teenage girl intentionally overdosed on 45 kratom capsules (500mg each = 22.5 grams or 4/5 ounce). After suffering from severe depression, the 15 year old obtained the capsules from her father, and swallowed them in an attempted suicide. On exam, patient complained of dry mouth, dizziness, restlessness, palpitations, nausea, …

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Inteview with Pharmacokineticist and Kratom Researcher Dr. Abhisheak Sharma

For audio of this interview as well as studies cited here see Kratom Science Podcast #45 KratomScience: You have your background in pharmacokinetics. What made you interested in going into that field? Dr. Abhisheak Sharma: So basically I did my PhD in 2015 and I moved to the States to do my post-doctoral studies with …

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Study: 7-hydroxymitragynine Metabolizes into the More Potent ‘Mitragynine Pseudoindoxyl’ in Human Plasma

A study out of University of Florida published in the journal ACS Pharmacology & Translational Science found that the potency of powder kratom may be due not only to the increased level of 7-hydroxymitragynine (7-HMG), but the way the 7-HMG metabolizes in human plasma (Kamble 2020). Fresh kratom consumed traditionally in Southeast Asia has been …

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Levels of Kratom Alkaloid Mitragynine Were Likely Overestimated in Autopsies

A research article in the journal Drug Testing and Analysis uncovered a flaw in previous examinations of kratom’s main alkaloid, mitragynine. The study, lead by University of Florida pharmacutics researcher Dr. Abisheak Sharma, stated: There is a possibility that earlier reported studies did not separate the four mitragynine diastereomers, resulting in over‐quantification of mitragynine in …

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Interview with Dr. Walter Prozialeck, Biomedical Educator and Kratom Researcher

Listen to this interview on Kratom Science Podcast #44 KratomScience: How do you pronounce your last name? Dr. Walter Prozialeck: Proh-jell-eck. It’s an old Ukrainian word that means “really bad golfer”. KS: *laughs* But I see you are a really good rugby player, it says on your Wikipedia page. WP: Well I used to be. …

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UF Researchers First to Grow Kratom for Published Study

In one of the first formal studies of its kind, if not the very first, a team from University of Florida cultivated 68 kratom trees and fertilized them at different rates, then measured for alkaloid content, chlorophyll, and total biomass. The study, “Effects of Nutrient Fertility on Growth and Alkaloidal Content in Mitragyna speciosa (Kratom)” …

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Plant Medicine: Cannabis, Kratom, and Psychedelics: An Interview with Dr. Zach Walsh

Audio version Kratom Science Podcast #42 KratomScience: Canada was one of the first countries to fully legalize cannabis. This was in 2018. Has there been an impact on the research that you can do in Canada because of legalization? Dr. Zach Walsh: Yes and no. The big moment for us with legalization and research really …

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