Journal Club with Dr. Jonathan Cachat

Dr. Jonathan Cachat joins Kratom Science Podcast host Brian Gallagher to talk about kratom research. Each episode we pick a study about kratom published in a peer-reviewed journal.

Journal Club #30: Can Light Therapy Relieve Opioid Craving?

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #30: Can Light Therapy Relieve Opioid Craving?
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This week we look at very interesting study led by Fredric Schiffer based on this theory of Dual Brain Psychology (DBP). DBP “posits that one brain hemisphere tends to be relatively mature and healthy, while the other hemisphere may be more affected by past traumas and supports a personality that is more prone to immature …

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**REPOST*** Journal Club #29: Kratom Toxicity and Medicolegal Issues, Cannabis Museum

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
**REPOST*** Journal Club #29: Kratom Toxicity and Medicolegal Issues, Cannabis Museum
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REPOST info: Yesterday I accidentally posted last week’s episode with this week’s information. I corrected this mistake 45 minutes after posting. Since the change is reflected on some listening apps and not others, I’m posting the episode again. Sorry! For #29 of Kratom Science Journal Club, JC and Brian look at a 2019 report on …

**REPOST*** Journal Club #29: Kratom Toxicity and Medicolegal Issues, Cannabis Museum Read More »

Journal Club #29: Kratom Toxicity and Medicolegal Issues, and the Cannabis Museum

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #29: Kratom Toxicity and Medicolegal Issues, and the Cannabis Museum
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For #29 of Kratom Science Journal Club, JC and Brian look at a 2019 report on toxicological events having to do with mitragynine. Does mitragynine increase the effects of other drugs? How toxic is kratom on its own? Other alkaloids have commonly been counted as mitragynine, so what are the ramifications? All this and other …

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Journal Club #28: Mitragynine Does Not Rely on 7-hydroxymitragynine for Pain Relief Effects

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #28: Mitragynine Does Not Rely on 7-hydroxymitragynine for Pain Relief Effects
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Dr. Cachat and host Brian Gallagher look at a groundbreaking study from University of Florida School of Pharmacy showing mitragynine has pain relieving effects independent of its metabolism into 7-hydroxymitragynine. This could be revolutionary in the study of kratom as a safer pain medicine. We go on to talk about the cannabis testing lab that …

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Journal Club #27: Does Kratom Kill…E-coli and Streptococcus Pneumoniae?

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #27: Does Kratom Kill...E-coli and Streptococcus Pneumoniae?
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Spoiler alert: kinda, but its more the quercetin in kratom, which is available in many food plants and as a dietary supplement on its own. This study comes to us from a team at Universitas Nahdlatul Ulama Surabaya (UNUSA) in Surabaya, Indonesia, on the island of Java, south of the island of Kalimantan, where most …

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Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice
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Dr. JC and Brian look at a study out of University of Science, Malaysia. The comprehensive and detailed study in mice from University of Science, Malaysia revealed mitragynine in very high doses is an agonist (binds to and activates) cannabinoid receptor Type 1 (CB1). Mice administered with high-dose mitragynine demonstrated similar reward-seeking behavior and cognitive …

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Journal Club #25: Dopamine Response to Mitragynine in Rats

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #25: Dopamine Response to Mitragynine in Rats
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Dr. Jon Cachat and host Brian Gallagher look at a study that examined dopamine levels with an electrochemical sensor in rats administered with various levels of mitragynine. Dopamine release was detected as significant levels after a high dose of mitragynine after 4 days. Questions explored in this episode include: Does this accurately measure the kratom …

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Journal Club #24: Kratom-Induced Psychosis? A Case Report

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #24: Kratom-Induced Psychosis? A Case Report
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Dr. Jonathan Cachat and host Brian Gallagher look at a case report of a supposed kratom-induced psychosis out of a student team from West Virginia University School of Medicine Department of Psychiatry, advised by MDs Alexander Muacevic and John R Adler. A 43 year old man combat veteran with six tours of duty, traumatic brain …

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Journal Club #23: Kratom alkaloid combo shown to help chemotherapy drug in killing cancer cells, more research needed

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #23: Kratom alkaloid combo shown to help chemotherapy drug in killing cancer cells, more research needed
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Please comment by August 9, 2021 to tell HHS/WHO to please keep kratom legal worldwide. Politely share your kratom story here, make sure you get a confirmation email and tracking number, and under “What are you commenting about?” Select “International Government – I0037” https://www.federalregister.gov/documents/2021/07/23/2021-15685/international-drug-scheduling-convention-on-psychotropic-substances-single-convention-on-narcotic?fbclid=IwAR1jTz7JSte491H5eTQBwjrivN4Y60s1t-kIPc1iy9UvnjfY2kkwHNFuBvM Disclaimer: None of the content on this podcast or on KratomScience.com …

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Journal Club #22: Accelerated Solvent Extracts of Kratom

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #22: Accelerated Solvent Extracts of Kratom
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Neuroscientist Dr. Jon Cachat and host Brian Gallagher look at a study from University of Science in Malaysia that studies kratom extracts using various solvents: water, methanol, ethanol, and ethyl acetate. The technique they use, accelerated solvent extracting, uses less time and a lower amount of solvent for a safer and more environmentally friendly extraction …

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