Journal Club #22: Accelerated Solvent Extracts of Kratom

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #22: Accelerated Solvent Extracts of Kratom

Neuroscientist Dr. Jon Cachat and host Brian Gallagher look at a study from University of Science in Malaysia that studies kratom extracts using various solvents: water, methanol, ethanol, and ethyl acetate. The technique they use, accelerated solvent extracting, uses less time and a lower amount of solvent for a safer and more environmentally friendly extraction technique. This technique has been established in botanical extractions, but is not commonly used for commercial kratom extracts. Some large kratom suppliers have been accused of outsourcing their extractions to China, and products come back containing toxic levels of residual solvents like chloroform and methanol, which could have serious health consequences. Further discussion is included on regulation of extracts, the benefits of extracts, the availability of full spectrum extracts (vs. extracts containing a single or only a few alkaloids), and how a kratom ban would exacerbate risks and dangers of contamination and adulteration especially in extract products. Shout out to Drew Turner for his comment on Twitter

Study referenced in this episode: Goh, Y. S., Karunakaran, T., Murugaiyah, V., Santhanam, R., Abu Bakar, M. H., & Ramanathan, S. (2021). Accelerated Solvent Extractions (ASE) of Mitragyna speciosa Korth. (Kratom) Leaves: Evaluation of Its Cytotoxicity and Antinociceptive Activity. Molecules (Basel, Switzerland), 26(12), 3704.


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Kratom Science Journal Club is produced by Brian Gallagher for

Disclaimer: There is no content on the Kratom Science Podcast nor on that in any way constitutes medical claims or medical advice. You should consult a medical professional for medical advice and we believe this sincerely. Take care.

2 thoughts on “Journal Club #22: Accelerated Solvent Extracts of Kratom”

  1. Hi! I didn’t see a way to contact via email so I’m commenting here. I have thoroughly enjoyed your podcast since discovering it! I wanted to request that you do an episode on sustainability of the plant and the effects of harvesting on the land. Thanks!

    1. Thank you and That’s a great idea! I used to be a small farmer and we tried to use as much sustainability as possible so it’s a topic I’ve studied. I may have the opportunity to interview kratom farmers soon. As far as I know, in its native regions, kratom farming is very environmentally friendly. According to quotes from scientists in the Indonesian press, the threats to outlaw kratom in Indonesia are threats to the environment and national parks there, since that would be eradicating millions of trees

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