Journal Club #14, Q&A Part 1: Kratom and Liver Enzymes, Alcohol, Pain Management, and Serotonin

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #14, Q&A Part 1: Kratom and Liver Enzymes, Alcohol, Pain Management, and Serotonin

Note: Nothing in this podcast or on is intended to be medical advice, nor should it be taken as such. We’re not medical doctors. Please don’t listen to podcasts for advice on what you should or should not put in your body.

For episode #14, Dr. Jonathan Cachat answers half of the remaining question from our February 23rd r/kratom Reddit AMA. There were so many questions, we divided this into two episodes.

In Part 1 questions are answered about kratom and liver enzymes, kratom in combination with alcohol and other substances, kratom vs. classical opioids for pain management, and is there any evidence of neurotoxicity with long-term kratom use?

AMA thread

Dr. Cachat can be reached on Twitter @jcachat or at

Kratom Science Podcast is produced by Brian Gallagher for

Other podcast episodes mentioned:

Studies cited in this episode:

Kamble, S. H., Sharma, A., King, T. I., León, F., McCurdy, C. R., & Avery, B. A. (2019). Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom). Xenobiotica; the fate of foreign compounds in biological systems, 49(11), 1279–1288.
Full Text

Johnson, L. E., Balyan, L., Magdalany, A., Saeed, F., Salinas, R., Wallace, S., Veltri, C. A., Swogger, M. T., Walsh, Z., & Grundmann, O. (2020). The Potential for Kratom as an Antidepressant and Antipsychotic. The Yale journal of biology and medicine, 93(2), 283–289.
Full Text

Singh, D., Ph.D, Narayanan, S., Ph.D, Müller, C. P., Ph.D, Vicknasingam, B., Ph.D, Yücel, M., Ph.D, Ho, E., Ph.D, Hassan, Z., Ph.D, & Mansor, S. M., Ph.D (2019). Long-Term Cognitive Effects of Kratom (Mitragyna speciosa Korth.) Use. Journal of psychoactive drugs, 51(1), 19–27.

Disclaimer: There is no content on the Kratom Science Podcast nor on that in any way constitutes medical claims or medical advice. You should consult a medical professional for medical advice and we believe this sincerely. Take care.

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