We all know the mitragynine and 7-hydroxymitraginine act on the mu-opioid receptor. But for episode #13 of Journal Club we talk about a study that looks closely at the binding affinity of various kratom alkaloids on the plethora of opioid and adrenergic receptors in the brain. How exactly does this work? How do different alkaloids lead to the multiple functional effects of kratom? Are we fish out of water when it comes to molecular chemistry? Guesses and possibly even answers, plus listener mail, in episode #13 of Kratom Science Journal Club.
Study cited in this episode:
Obeng, S., Kamble, S. H., Reeves, M. E., Restrepo, L. F., Patel, A., Behnke, M., Chear, N. J., Ramanathan, S., Sharma, A., León, F., Hiranita, T., Avery, B. A., McMahon, L. R., & McCurdy, C. R. (2020). Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. Journal of medicinal chemistry, 63(1), 433–439. https://doi.org/10.1021/acs.jmedchem.9b01465
Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676998/
Check out the upcoming AMA (Ask Me Anything) with Dr. Jonathan Cachat on https://www.reddit.com/r/kratom/
Kratom Science Journal Club is produced by Brian Gallagher for KratomScience.com