45. Dr. Abisheak Sharma, Pharmacokineticist and Kratom Researcher

Kratom Science
45. Dr. Abisheak Sharma, Pharmacokineticist and Kratom Researcher
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Dr. Abisheak Sharma studied pharmacy and pharmacokinetics in India before coming to the United States to research under kratom expert Dr. Bonnie Avery. He now researches kratom with Dr. Christopher McCurdy at University of Florida as part of the Translational Drug Development Core. Dr. Sharma addresses the concern with kratom and other drug interactions, improved chromatography methods of identifying kratom alkaloids, research on kratom plants being grown by University of Florida, and where we are with kratom and human clinical trials.

A full transcription of this podcast is forthcoming and will be linked here

Music: Risey, “Memories of Thailand”

The Kratom Science Podcast is written and produced by Brian Gallagher for KratomScience.com

Dr. Sharma’s UFL profile https://pharmacy.ufl.edu/profile/sharma-abhisheak/
Translational Drug Development Core https://www.ctsi.ufl.edu/research/laboratory-services/translational-drug-development-core

Studies Cited in this episode:

Zhang, M., Sharma, A., León, F., Avery, B., Kjelgren, R., McCurdy, C. R., & Pearson, B. J. (2020). Effects of Nutrient Fertility on Growth and Alkaloidal Content in Mitragyna speciosa (Kratom). Frontiers in plant science, 11, 597696. https://doi.org/10.3389/fpls.2020.597696
Full Text https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779599/

Sharma, A., & McCurdy, C. R. (2020). Assessing the therapeutic potential and toxicity of Mitragyna speciosa in opioid use disorder. Expert opinion on drug metabolism & toxicology, 1–3. Advance online publication. https://doi.org/10.1080/17425255.2021.1853706
Full Text https://www.tandfonline.com/doi/full/10.1080/17425255.2021.1853706

Kruegel, A. C., Uprety, R., Grinnell, S. G., Langreck, C., Pekarskaya, E. A., Le Rouzic, V., Ansonoff, M., Gassaway, M. M., Pintar, J. E., Pasternak, G. W., Javitch, J. A., Majumdar, S., & Sames, D. (2019). 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects. ACS central science, 5(6), 992–1001. https://doi.org/10.1021/acscentsci.9b00141
Full Text https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598159/

Trakulsrichai, S., Sathirakul, K., Auparakkitanon, S., Krongvorakul, J., Sueajai, J., Noumjad, N., Sukasem, C., & Wananukul, W. (2015). Pharmacokinetics of mitragynine in man. Drug design, development and therapy, 9, 2421–2429. https://doi.org/10.2147/DDDT.S79658
Full Text https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425236/

Kamble, S. H., Sharma, A., King, T. I., Berthold, E. C., León, F., Meyer, P., Kanumuri, S., McMahon, L. R., McCurdy, C. R., & Avery, B. A. (2020). Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids. Toxicology letters, 319, 148–154. https://doi.org/10.1016/j.toxlet.2019.11.005
Full Text https://www.sciencedirect.com/science/article/abs/pii/S037842741930356X?via%3Dihub

Kamble, S. H., León, F., King, T. I., Berthold, E. C., Lopera-Londoño, C., Siva Rama Raju, K., Hampson, A. J., Sharma, A., Avery, B. A., McMahon, L. R., & McCurdy, C. R. (2020). Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy. ACS pharmacology & translational science, 3(6), 1063–1068. https://doi.org/10.1021/acsptsci.0c00075

Obeng, S., Kamble, S. H., Reeves, M. E., Restrepo, L. F., Patel, A., Behnke, M., Chear, N. J., Ramanathan, S., Sharma, A., León, F., Hiranita, T., Avery, B. A., McMahon, L. R., & McCurdy, C. R. (2020). Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. Journal of medicinal chemistry, 63(1), 433–439. https://doi.org/10.1021/acs.jmedchem.9b01465
Full Text https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676998/

Sharma, A., Kamble, S. H., León, F., Chear, N. J., King, T. I., Berthold, E. C., Ramanathan, S., McCurdy, C. R., & Avery, B. A. (2019). Simultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultra-performance liquid chromatography-tandem mass spectrometry. Drug testing and analysis, 11(8), 1162–1171. https://doi.org/10.1002/dta.2604

Wilson, L. L., Harris, H. M., Eans, S. O., Brice-Tutt, A. C., Cirino, T. J., Stacy, H. M., Simons, C. A., León, F., Sharma, A., Boyer, E. W., Avery, B. A., McLaughlin, J. P., & McCurdy, C. R. (2020). Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence. Drug and alcohol dependence, 216, 108310. https://doi.org/10.1016/j.drugalcdep.2020.108310
Full Text https://www.sciencedirect.com/science/article/abs/pii/S0376871620304750?via%3Dihub

Avery, B. A., Boddu, S. P., Sharma, A., Furr, E. B., Leon, F., Cutler, S. J., & McCurdy, C. R. (2019). Comparative Pharmacokinetics of Mitragynine after Oral Administration of Mitragyna speciosa (Kratom) Leaf Extracts in Rats. Planta medica, 85(4), 340–346. https://doi.org/10.1055/a-0770-3683

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