Journal Club #10: Kratom and Alcohol

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #10: Kratom and Alcohol

Happy Thanksgiving! The holidays after a rough year are always a great time to drink like a fish. In this episode we explore kratom and alcohol. Emerging testimony and research indicates kratom may be an effective harm reduction tool to cut down on alcohol consumption, withdrawal, and cravings. We read testimony from commenters, then get into a study showing four isolated kratom alkaloids all decreased alcohol consumption in mice.

Article discussed in this episode: Gutridge AM, Robins MT, Cassell RJ, Uprety R, Mores KL, Ko MJ, Pasternak GW, Majumdar S, van Rijn RM. G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder. Br J Pharmacol. 2020 Apr;177(7):1497-1513. doi: 10.1111/bph.14913. Epub 2020 Jan 24. PMID: 31705528; PMCID: PMC7060366.
Full text (open access):

Dr. Jonthan Cachat can be found on Twitter @jcachat and at

Music: Captain Bigwheel “Moonrunner”

Kratom Science Journal Club is produced by Brian Gallagher for

Disclaimer: There is no content on the Kratom Science Podcast nor on that in any way constitutes medical claims or medical advice. You should consult a medical professional for medical advice and we believe this sincerely. Take care.

1 thought on “Journal Club #10: Kratom and Alcohol”

  1. Interesting podcast and it makes total sense to me. I was a hardcore alcoholic for many many years and tried everything multiple rehabs. I found kratom around 2 years ago and my cravings and honestly my complete addiction to alcohol and diminished to nothing. I know pass alcohol isles and have no feeling torward it and couldn’t drink even if I wanted to now. However I do take kratom a couple times a day every day but for me that’s better then a black out drunk that destroyed over 10 years with alcohol. Wanted to post maybe someone in bad shape can have some hope. Thanks!

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