Happy Thanksgiving! The holidays after a rough year are always a great time to drink like a fish. In this episode we explore kratom and alcohol. Emerging testimony and research indicates kratom may be an effective harm reduction tool to cut down on alcohol consumption, withdrawal, and cravings. We read testimony from KratomScience.com commenters, then get into a study showing four isolated kratom alkaloids all decreased alcohol consumption in mice.
Article discussed in this episode: Gutridge AM, Robins MT, Cassell RJ, Uprety R, Mores KL, Ko MJ, Pasternak GW, Majumdar S, van Rijn RM. G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder. Br J Pharmacol. 2020 Apr;177(7):1497-1513. doi: 10.1111/bph.14913. Epub 2020 Jan 24. PMID: 31705528; PMCID: PMC7060366.
Full text (open access): https://bpspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/bph.14913
Dr. Jonthan Cachat can be found on Twitter @jcachat and at ccvresearch.com
Music: Captain Bigwheel “Moonrunner”
Kratom Science Journal Club is produced by Brian Gallagher for KratomScience.com