Journal Club with Dr. Jonathan Cachat

Dr. Jonathan Cachat joins Kratom Science Podcast host Brian Gallagher to talk about kratom research. Each episode we pick a study about kratom published in a peer-reviewed journal.

Journal Club #11: Pivotal Mental States, Psychedelics, and Bio-Psycho-Social Studies

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #11: Pivotal Mental States, Psychedelics, and Bio-Psycho-Social Studies
/

This great Journal of Psychopharmacology article on “Pivotal Mental States” led to a wide ranging discussion with Dr. Jonathan Cachat about the bio-psycho-social study of mental states, use of psychedelics in a therapeutic setting, spirituality and religion, the rapidly changing modern mental landscape, positive mental attitude, and why the immensity, plasticity, and adaptability of the …

Journal Club #11: Pivotal Mental States, Psychedelics, and Bio-Psycho-Social Studies Read More »

Journal Club #10: Kratom and Alcohol

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #10: Kratom and Alcohol
/

Happy Thanksgiving! The holidays after a rough year are always a great time to drink like a fish. In this episode we explore kratom and alcohol. Emerging testimony and research indicates kratom may be an effective harm reduction tool to cut down on alcohol consumption, withdrawal, and cravings. We read testimony from KratomScience.com commenters, then …

Journal Club #10: Kratom and Alcohol Read More »

Journal Club #9: Speciofoline, the Understudied Alkaloid

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #9: Speciofoline, the Understudied Alkaloid
/

A study on kratom’s chemical composition asks, what does the little-researched kratom alkaloid speciofoline do? And what are the implications for drug interactions and the differences in alkaloid content in kratom products? The brand new study published last week in Scientific Reports examined the chemical composition of 53 kratom products and divided them into two …

Journal Club #9: Speciofoline, the Understudied Alkaloid Read More »

Journal Club #8: Kratom Tea for Opioid Dependence in Mice

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #8: Kratom Tea for Opioid Dependence in Mice
/

This week we look at a study by a team from University of Florida called “Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence”. The science is catching up with what thousands of kratom consumers are saying — that kratom can be a safe and effective harm reduction tool for opioid withdrawal and dependence. …

Journal Club #8: Kratom Tea for Opioid Dependence in Mice Read More »

Journal Club #7: Kratom Use and Mental Health w/ Dr. Marc Swogger and Dr. Jonathan Cachat

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #7: Kratom Use and Mental Health w/ Dr. Marc Swogger and Dr. Jonathan Cachat
/

Host Brian Gallagher and Dr. Jonathan Cachat welcome Dr. Marc Swogger, social scientist and clinical psychologist at the University of Rochester Medical Center to discuss his 2018 article published in Drug and Alcohol Dependence “Kratom Use and Mental Health: A Systematic Review”. Along with co-author Zach Walsh, Dr. Swogger looked at all the literature published …

Journal Club #7: Kratom Use and Mental Health w/ Dr. Marc Swogger and Dr. Jonathan Cachat Read More »

Journal Club #6: 1972 Animal Study Shows the Promise of Mitragynine

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #6: 1972 Animal Study Shows the Promise of Mitragynine
/

Citation: Macko E, Weisbach JA, Douglas B. Some observations on the pharmacology of mitragynine. Archives Internationales de Pharmacodynamie et de Therapie. 1972 ;198(1):145-161. We discuss this study from 1972 that tested the effects of mitragynine in rats, mice, cats, dogs, and monkeys. Dr. Jon talks about the difference between now and then in pharmacology labs. …

Journal Club #6: 1972 Animal Study Shows the Promise of Mitragynine Read More »

Journal Club w/ Dr. Jonathan Cachat #5: Mitragynine Study in Rats Leads to Interesting Conclusions

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club w/ Dr. Jonathan Cachat #5: Mitragynine Study in Rats Leads to Interesting Conclusions
/

Dr. Cachat and I talk about a study that tested rats with morphine, mitragynine, naloxone, buprenorphine, and rimonabant, and measured responses based on food-reinforcement training. The study concluded “The findings suggest that MG does not induce physiological dependence but can alleviate the physical symptoms associated with morphine withdrawal”. We talk about how the rats are …

Journal Club w/ Dr. Jonathan Cachat #5: Mitragynine Study in Rats Leads to Interesting Conclusions Read More »

Journal Club w/ Dr. Jonathan Cachat #4: Human Evolution and Psychoactive Plants, Scratching the Surface of Kratom History, and Kratom Alkaloids

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club w/ Dr. Jonathan Cachat #4: Human Evolution and Psychoactive Plants, Scratching the Surface of Kratom History, and Kratom Alkaloids
/

This episode, Dr. Jon and I use the journal article “Following the Roots of Kratom” published in 2015 by BioMed Research International as a jumping off point to talk about kratom history, human evolution and psychoactive plants, Terence McKenna’s “Stoned Ape” theory, and drug in religious cults . Plus, we answer listener mail about kratom …

Journal Club w/ Dr. Jonathan Cachat #4: Human Evolution and Psychoactive Plants, Scratching the Surface of Kratom History, and Kratom Alkaloids Read More »

Journal Club with Dr Jonathan Cachat #3: Kratom Addiction, Listener Mail, and Elephants on LSD

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club with Dr Jonathan Cachat #3: Kratom Addiction, Listener Mail, and Elephants on LSD
/

Dr. Jon Cachat and I talk about the article “Kratom instrumentalization for severe pain self-treatment resulting in addiction – A case report of acute and chronic subjective effects” – This is an open access article that you can read for free https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378692/ Müller, E., Hillemacher, T., & Müller, C. P. (2020). Kratom instrumentalization for severe …

Journal Club with Dr Jonathan Cachat #3: Kratom Addiction, Listener Mail, and Elephants on LSD Read More »

Journal Club with Dr. Jonathan Cachat #2: “The Potential for Kratom as an Antidepressant and Antipsychotic”

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat #2: "The Potential for Kratom as an Antidepressant and Antipsychotic"
/

This is the Kratom Science Journal Club with Dr. Jonathan Cachat, neuroscientist and expert in psychopharmacology. In each episode we discuss an article in a peer reviewed journal. For episode 2 we discuss the article, “The Potential for Kratom as an Antidepressant and Antipsychotic” published in Yale Journal of Biology and Medicine, edition 93, June …

Journal Club with Dr. Jonathan Cachat #2: “The Potential for Kratom as an Antidepressant and Antipsychotic” Read More »