Citation: Macko E, Weisbach JA, Douglas B. Some observations on the pharmacology of mitragynine. Archives Internationales de Pharmacodynamie et de Therapie. 1972 ;198(1):145-161.
We discuss this study from 1972 that tested the effects of mitragynine in rats, mice, cats, dogs, and monkeys. Dr. Jon talks about the difference between now and then in pharmacology labs. Similar conclusions about the effects of mitragynine and its relative safety in relation to opiates, but why was mitragynine never developed as a pain management drug, especially by the company that conducted this study, that would later merge into pharmaceutical giant Glaxo SmithKline? We examine how a mitragynine dose as high as 920 mg/kg in a mouse produced no evidence of toxicity. And a bit about mitragynine and metabolism.
Music: Captain Bigwheel, “Moonrunner”
Produced by Brian Gallagher for KratomScience.com