alkaloids

Journal Club #38: Mitragynine in Kratom Trees in Thailand

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #38: Mitragynine in Kratom Trees in Thailand
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Thailand has recently decriminalized kratom after 79 years of prohibition. In today’s episode of Kratom Science Journal Club, Dr. Cachat and Brian look at a study funded in part by the Thai government that analyzed kratom trees growing in various regions of Thailand. The team measured mitragynine levels, accounting for variables in climate such as …

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Scientists study mitragynine levels in Thai kratom

In a study published in October in Frontiers in Plant Science, researchers collected leaves from kratom trees in various regions of Thailand to measure mitragynine (MG) levels, and to account for environmental variables that may influence the alkaloid content. The team from Kasetsart University in Bangkok found a range of mitragynine content, from 7.5 to …

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Journal Club #28: Mitragynine Does Not Rely on 7-hydroxymitragynine for Pain Relief Effects

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #28: Mitragynine Does Not Rely on 7-hydroxymitragynine for Pain Relief Effects
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Dr. Cachat and host Brian Gallagher look at a groundbreaking study from University of Florida School of Pharmacy showing mitragynine has pain relieving effects independent of its metabolism into 7-hydroxymitragynine. This could be revolutionary in the study of kratom as a safer pain medicine. We go on to talk about the cannabis testing lab that …

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69. Dr. Christopher McCurdy and Dr. Brian Pearson on the Future of Kratom

Kratom Science Podcast
Kratom Science Podcast
69. Dr. Christopher McCurdy and Dr. Brian Pearson on the Future of Kratom
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Dr. Chris McCurdy is a medicinal chemist who has done groundbreaking research on kratom since 2004, starting at the University of Mississippi. In 2017 Dr. McCurdy moved to the University of Florida College of Pharmacy where he continues his research today with an expert team of pharmacologists, unlocking the function of kratom’s many alkaloids and …

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Journal Club #25: Dopamine Response to Mitragynine in Rats

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #25: Dopamine Response to Mitragynine in Rats
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Dr. Jon Cachat and host Brian Gallagher look at a study that examined dopamine levels with an electrochemical sensor in rats administered with various levels of mitragynine. Dopamine release was detected as significant levels after a high dose of mitragynine after 4 days. Questions explored in this episode include: Does this accurately measure the kratom …

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59. Dr. Lance McMahon, Chair of University of Florida College of Pharmacy Dept of Pharmacodynamics

Kratom Science Podcast
Kratom Science Podcast
59. Dr. Lance McMahon, Chair of University of Florida College of Pharmacy Dept of Pharmacodynamics
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Dr. Lance McMahon is Chair of the Department of Pharmacodynamics at University of Florida College of Pharmacy, a college that has been at the forefront of kratom research. Dr. McMahon studies the mechanism of action of the multiple kratom alkaloids and how they function alone and in concert on our various brain receptors. His lab …

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Journal Club #22: Accelerated Solvent Extracts of Kratom

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #22: Accelerated Solvent Extracts of Kratom
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Neuroscientist Dr. Jon Cachat and host Brian Gallagher look at a study from University of Science in Malaysia that studies kratom extracts using various solvents: water, methanol, ethanol, and ethyl acetate. The technique they use, accelerated solvent extracting, uses less time and a lower amount of solvent for a safer and more environmentally friendly extraction …

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Interview with Dr. Oliver Grundmann, Professor of Medicinal Chemistry and Kratom Researcher, University of Florida

An audio version of this interview can be found on the Kratom Science Podcast #40 Kratom Science: How did you become involved with studying kratom? Oliver Grundmann: It’s an interesting way, how I got involved with kratom. In 2015 one of my Masters students who works in the forensic field with a forensic toxicology lab …

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Journal Club #16: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #16: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract
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Another study from University of Florida is the “first report that has simultaneously evaluated the systemic exposure of 11 kratom alkaloids following the administration of traditional and commercial kratom products” (Kamble, 2021). Researchers looked at the pharmacokinectics (how drugs move through the body and are metabolized) of alkaloids in rat plasma following the oral administration …

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Inteview with Pharmacokineticist and Kratom Researcher Dr. Abhisheak Sharma

For audio of this interview as well as studies cited here see Kratom Science Podcast #45 KratomScience: You have your background in pharmacokinetics. What made you interested in going into that field? Dr. Abhisheak Sharma: So basically I did my PhD in 2015 and I moved to the States to do my post-doctoral studies with …

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