For audio of this interview as well as studies cited here see Kratom Science Podcast #45 KratomScience: You have your background in pharmacokinetics. What made you interested in going into that field? Dr. Abhisheak Sharma: So basically I did my PhD in 2015 and I moved to the States to do my post-doctoral studies with …
Inteview with Pharmacokineticist and Kratom Researcher Dr. Abhisheak Sharma Read More »
A study out of University of Florida published in the journal ACS Pharmacology & Translational Science found that the potency of powder kratom may be due not only to the increased level of 7-hydroxymitragynine (7-HMG), but the way the 7-HMG metabolizes in human plasma (Kamble 2020). Fresh kratom consumed traditionally in Southeast Asia has been …
We all know the mitragynine and 7-hydroxymitraginine act on the mu-opioid receptor. But for episode #13 of Journal Club we talk about a study that looks closely at the binding affinity of various kratom alkaloids on the plethora of opioid and adrenergic receptors in the brain. How exactly does this work? How do different alkaloids …
Journal Club #13: How Kratom Alkaloids Act on Brain Receptors Read More »
My guest is Dr. Walter Prozialeck. Originally from Johnstown, PA, Dr. Prozialeck is a biomedical educator and researcher at Midwestern University in Chicago, where he served as chair of the Department of Pharmacology from 1997 to 2018. He’s been studying kratom since 2012. We talk about one of the first research reviews published on kratom …
44. Biomedical Educator and Research Scientist Dr. Walter Prozialeck Read More »
Mitragynine is the most abundant alkaloid in kratom. Kratom contains about 40 alkaloids that we know of. All of the alkaloids combined make up only 0.5-1.5% of the total leaf material. Estimates of percentage of mitragynine in alkaloids range from 12% in Malaysian kratom to 66% in Thai kratom. If alkaloids make up only 1% …
Citation: Macko E, Weisbach JA, Douglas B. Some observations on the pharmacology of mitragynine. Archives Internationales de Pharmacodynamie et de Therapie. 1972 ;198(1):145-161. We discuss this study from 1972 that tested the effects of mitragynine in rats, mice, cats, dogs, and monkeys. Dr. Jon talks about the difference between now and then in pharmacology labs. …
Journal Club #6: 1972 Animal Study Shows the Promise of Mitragynine Read More »
Article Citation with Link to Full Text Harun N, Johari IS, Mansor SM, Shoaib M. Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats. Psychopharmacology (Berl). 2020;237(3):855-867. doi:10.1007/s00213-019-05418-6 Summary by KratomScience Rats were studied in two separate experiments: Experiment 1: Observing withdrawal in rats given morphine vs. rats given mitragynine Three …
Dr. Jonathan Cachat is a neuroscientist and expert in psychopharmacology, who has extensively studied the effects of psychoactive substances on zebrafish. Dr. Cachat was involved in pioneering the first ever cannabis lab technician program at Hocking College in Ohio. He is currently involved in digitizing pre-prohibition research for the Cannabis Museum in Cincinnati. Dr. Cachat …
28. The Importance of Public Policy with Neuroscientist, Dr. Jonathan Cachat Read More »
My guest is Dr. Marc Swogger from the University of Rochester Medical Center, Department of Psychiatry. Dr. Swogger is a social scientist and psychologist who studies substance use. He has co-authored multiple studies on the individual and public health effects of the use of kratom. Studies discussed in this interview: Marc T. Swogger, Elaine Hart, …
23. Social Scientist and Psychologist, Dr. Marc Swogger Read More »
Andy Knowles was a Chief Gunners Mate until he was recently kicked out of the United States Navy after a 15 year career, just for using kratom. Andy wasn’t aware kratom was banned by the military, and it was helping him function with depression and anxiety. Kratom is, in fact, on the Department of Defense’s …
