Toxic Levels of Kratom and LD50 of Mitragynine
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Toxic Levels of Kratom and LD50 of Mitragynine

Mitragynine is the most abundant alkaloid in kratom. Kratom contains about 40 alkaloids that we know of. All of the alkaloids combined make up only 0.5-1.5% of the total leaf…

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6. Journal Club with Dr. Jonathan Cachat – 1972 Animal Study Shows the Promise of Mitragynine

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Citation: Macko E, Weisbach JA, Douglas B. Some observations on the pharmacology of mitragynine. Archives Internationales de Pharmacodynamie et de Therapie. 1972 ;198(1):145-161. We discuss this study from 1972 that…

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Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine
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Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine

Article Citation with Link to Full Text Harun N, Johari IS, Mansor SM, Shoaib M. Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats. Psychopharmacology (Berl).…

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28. Dr. Jonathan Cachat

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Dr. Jonathan Cachat is a neuroscientist and expert in psychopharmacology, who has extensively studied the effects of psychoactive substances on zebrafish. Dr. Cachat was involved in pioneering the first ever…

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23. Marc Swogger

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My guest is Dr. Marc Swogger from the University of Rochester Medical Center, Department of Psychiatry. Dr. Swogger is a social scientist and psychologist who studies substance use. He has…

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16. Andy Knowles

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My guest is Andy Knowles. He is a Chief Gunners Mate who was recently kicked out of the United States Navy after a 15 year career, just for using kratom.…

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