drugs

47. Take it as a Tea with Hamilton’s Pharmacopeia Producer Soren Shade

Kratom Science
47. Take it as a Tea with Hamilton's Pharmacopeia Producer Soren Shade
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Soren Shade grew up in the woods of West Virginia. Through a program for low-income, high-achieving students, he studied philosophy at Columbia University in New York. In his senior year he worked research assistant for Hamilton Morris and ended up as a producer on Season 3 of Hamilton’s Pharmacopeia, released earlier this year. Soren is …

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16. Journal Club: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract

Kratom Science
16. Journal Club: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract
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Another study from University of Florida is the “first report that has simultaneously evaluated the systemic exposure of 11 kratom alkaloids following the administration of traditional and commercial kratom products” (Kamble, 2021). Researchers looked at the pharmacokinectics (how drugs move through the body and are metabolized) of alkaloids in rat plasma following the oral administration …

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15. Journal Club Q&A Part 2: Kratom Legality, Kratom and Pharma, Dopamine Agonists, Libido, and Random Effects

Kratom Science
15. Journal Club Q&A Part 2: Kratom Legality, Kratom and Pharma, Dopamine Agonists, Libido, and Random Effects
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Note: Nothing in this podcast or on KratomScience.com is intended to be medical advice, nor should it be taken as such. We’re not medical doctors. Please don’t listen to podcasts for advice on what you should or should not put in your body. Dr. Cachat continues answering questions from February’s r/kratom Ask Me Anything. This …

15. Journal Club Q&A Part 2: Kratom Legality, Kratom and Pharma, Dopamine Agonists, Libido, and Random Effects Read More »

Inteview with Pharmacokineticist and Kratom Researcher Dr. Abhisheak Sharma

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For audio of this interview as well as studies cited here see Kratom Science Podcast #45 KratomScience: You have your background in pharmacokinetics. What made you interested in going into that field? Dr. Abhisheak Sharma: So basically I did my PhD in 2015 and I moved to the States to do my post-doctoral studies with …

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Study: 7-hydroxymitragynine Metabolizes into the More Potent ‘Mitragynine Pseudoindoxyl’ in Human Plasma

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A study out of University of Florida published in the journal ACS Pharmacology & Translational Science found that the potency of powder kratom may be due not only to the increased level of 7-hydroxymitragynine (7-HMG), but the way the 7-HMG metabolizes in human plasma (Kamble 2020). Fresh kratom consumed traditionally in Southeast Asia has been …

Study: 7-hydroxymitragynine Metabolizes into the More Potent ‘Mitragynine Pseudoindoxyl’ in Human Plasma Read More »

13. Journal Club: How Kratom Alkaloids Act on Brain Receptors

Kratom Science
13. Journal Club: How Kratom Alkaloids Act on Brain Receptors
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We all know the mitragynine and 7-hydroxymitraginine act on the mu-opioid receptor. But for episode #13 of Journal Club we talk about a study that looks closely at the binding affinity of various kratom alkaloids on the plethora of opioid and adrenergic receptors in the brain. How exactly does this work? How do different alkaloids …

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44. Biomedical Educator and Research Scientist Dr. Walter Prozialeck

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44. Biomedical Educator and Research Scientist Dr. Walter Prozialeck
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My guest is Dr. Walter Prozialeck. Originally from Johnstown, PA, Dr. Prozialeck is a biomedical educator and researcher at Midwestern University in Chicago, where he served as chair of the Department of Pharmacology from 1997 to 2018. He’s been studying kratom since 2012. We talk about one of the first research reviews published on kratom …

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6. Journal Club with Dr. Jonathan Cachat – 1972 Animal Study Shows the Promise of Mitragynine

Kratom Science
6. Journal Club with Dr. Jonathan Cachat - 1972 Animal Study Shows the Promise of Mitragynine
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Citation: Macko E, Weisbach JA, Douglas B. Some observations on the pharmacology of mitragynine. Archives Internationales de Pharmacodynamie et de Therapie. 1972 ;198(1):145-161. We discuss this study from 1972 that tested the effects of mitragynine in rats, mice, cats, dogs, and monkeys. Dr. Jon talks about the difference between now and then in pharmacology labs. …

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Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine

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Article Citation with Link to Full Text Harun N, Johari IS, Mansor SM, Shoaib M. Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats. Psychopharmacology (Berl). 2020;237(3):855-867. doi:10.1007/s00213-019-05418-6 Summary by KratomScience Rats were studied in two separate experiments: Experiment 1: Observing withdrawal in rats given morphine vs. rats given mitragynine Three …

Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine Read More »