drugs | Kratom Science

Journal Club #25: Dopamine Response to Mitragynine in Rats

Journal Club with Dr. Jonathan Cachat

Journal Club #25: Dopamine Response to Mitragynine in Rats

00:00 / 35:37

Dr. Jon Cachat and host Brian Gallagher look at a study that examined dopamine levels with an electrochemical sensor in rats administered with various levels of mitragynine. Dopamine release was detected as significant levels after a high dose of mitragynine after 4 days. Questions explored in this episode include: Does this accurately measure the kratom …

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59. Dr. Lance McMahon, Chair of University of Florida College of Pharmacy Dept of Pharmacodynamics

Kratom Science Podcast

59. Dr. Lance McMahon, Chair of University of Florida College of Pharmacy Dept of Pharmacodynamics

00:00 / 1:02:00

Dr. Lance McMahon is Chair of the Department of Pharmacodynamics at University of Florida College of Pharmacy, a college that has been at the forefront of kratom research. Dr. McMahon studies the mechanism of action of the multiple kratom alkaloids and how they function alone and in concert on our various brain receptors. His lab …

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Combining traditional plant medicine with modern medical technology

Leave a Comment / General, Research, Uncategorized / By Brian

A pharmacologist today may regard traditional and plant medicine as primitive, and may entirely disregard thousands of years of use and thousands of modern-day testimonies of positive outcomes because it has not been through the rigors of hard science. On the other hand, the massive spread of anti-science misinformation has cast sometimes unreasonable doubt on …

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55. Dr. Kirsten Smith of National Institute on Drug Abuse (NIDA)

Kratom Science Podcast

55. Dr. Kirsten Smith of National Institute on Drug Abuse (NIDA)

00:00 / 58:27

Dr. Kirsten Smith is a post-doc fellow at National Institute on Drug Abuse. With a background in social work and working with communities with substance use disorder, Dr. Smith was instrumental in introducing kratom research to NIDA’s Intramural Research Program, where she works in the in the Real-world Assessment, Prediction, and Treatment Unit. Dr. Smith …

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54. Afghanistan War Veteran Jaclyn O’Shea on surviving war, her husband’s suicide, and PTSD

Kratom Science Podcast

54. Afghanistan War Veteran Jaclyn O'Shea on surviving war, her husband's suicide, and PTSD

00:00 / 40:09

Jaclyn O’Shea has such a rich story that we couldn’t possibly tell it all in this short conversation. She is a United States Army veteran who served two tours in the War in Afghanistan. Her husband fought in Iraq in the Battle of Fallujah. He became one of several veterans in that battle who suffered …

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Journal Club #21: Heroin to Buprenorphine to Kratom in Appalachia

Journal Club with Dr. Jonathan Cachat

Journal Club #21: Heroin to Buprenorphine to Kratom in Appalachia

00:00 / 47:25

Study examined in this episode: Smith, K. E., Bunting, A. M., Walker, R., Hall, M. T., Grundmann, O., & Castillo, O. (2019). Non-Prescribed Buprenorphine Use Mediates the Relationship between Heroin Use and Kratom Use among a Sample of Polysubstance Users. Journal of psychoactive drugs, 51(4), 311–322. https://doi.org/10.1080/02791072.2019.1597224Pubmed link https://pubmed.ncbi.nlm.nih.gov/30961450/ Link to all studies covered on …

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Interview with Dr. Oliver Grundmann, Professor of Medicinal Chemistry and Kratom Researcher, University of Florida

1 Comment / General, Research / By Brian

An audio version of this interview can be found on the Kratom Science Podcast #40 Kratom Science: How did you become involved with studying kratom? Oliver Grundmann: It’s an interesting way, how I got involved with kratom. In 2015 one of my Masters students who works in the forensic field with a forensic toxicology lab …

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Journal Club #18: Pineal Gland and DMT Facts and Myth

Journal Club with Dr. Jonathan Cachat

Journal Club #18: Pineal Gland and DMT Facts and Myth

00:00 / 39:53

In a departure from kratom science, Dr. Cachat and Brian look at a paper by a pioneering pharmacologist and researcher in the field of psychedelics, Dr. David E. Nichols. Dr. Nichols methodically lays out his case for why endogenous DMT produced in the pineal gland, brain, or other parts of the human body is not …

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49. Comedian Shane Mauss Talks Science Podcasting and Kratom

Kratom Science Podcast

49. Comedian Shane Mauss Talks Science Podcasting and Kratom

00:00 / 1:12:02

Shane Mauss is a stand up comedian who has appeared on Late Night with Conan O’Brien, Jimmy Kimmel Live, The Joe Rogan Experience, WTF with Marc Maron, Comedy Central, The Green Room with Paul Provenza, and Getting Doug with High, just to name a few. For the past 7 years he’s interviewed scientists on a …

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47. Take it as a Tea with Hamilton’s Pharmacopeia Producer Soren Shade

Kratom Science Podcast

47. Take it as a Tea with Hamilton's Pharmacopeia Producer Soren Shade

00:00 / 55:21

Soren Shade grew up in the woods of West Virginia. Through a program for low-income, high-achieving students, he studied philosophy at Columbia University in New York. In his senior year he worked research assistant for Hamilton Morris and ended up as a producer on Season 3 of Hamilton’s Pharmacopeia, released earlier this year. Soren is …

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