science

47. Take it as a Tea with Hamilton’s Pharmacopeia Producer Soren Shade

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47. Take it as a Tea with Hamilton's Pharmacopeia Producer Soren Shade
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Soren Shade grew up in the woods of West Virginia. Through a program for low-income, high-achieving students, he studied philosophy at Columbia University in New York. In his senior year he worked research assistant for Hamilton Morris and ended up as a producer on Season 3 of Hamilton’s Pharmacopeia, released earlier this year. Soren is …

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16. Journal Club: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract

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16. Journal Club: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract
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Another study from University of Florida is the “first report that has simultaneously evaluated the systemic exposure of 11 kratom alkaloids following the administration of traditional and commercial kratom products” (Kamble, 2021). Researchers looked at the pharmacokinectics (how drugs move through the body and are metabolized) of alkaloids in rat plasma following the oral administration …

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Inteview with Pharmacokineticist and Kratom Researcher Dr. Abhisheak Sharma

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For audio of this interview as well as studies cited here see Kratom Science Podcast #45 KratomScience: You have your background in pharmacokinetics. What made you interested in going into that field? Dr. Abhisheak Sharma: So basically I did my PhD in 2015 and I moved to the States to do my post-doctoral studies with …

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Study: 7-hydroxymitragynine Metabolizes into the More Potent ‘Mitragynine Pseudoindoxyl’ in Human Plasma

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A study out of University of Florida published in the journal ACS Pharmacology & Translational Science found that the potency of powder kratom may be due not only to the increased level of 7-hydroxymitragynine (7-HMG), but the way the 7-HMG metabolizes in human plasma (Kamble 2020). Fresh kratom consumed traditionally in Southeast Asia has been …

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44. Biomedical Educator and Research Scientist Dr. Walter Prozialeck

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44. Biomedical Educator and Research Scientist Dr. Walter Prozialeck
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My guest is Dr. Walter Prozialeck. Originally from Johnstown, PA, Dr. Prozialeck is a biomedical educator and researcher at Midwestern University in Chicago, where he served as chair of the Department of Pharmacology from 1997 to 2018. He’s been studying kratom since 2012. We talk about one of the first research reviews published on kratom …

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12. Journal Club: Kratom Cultivation Studied

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12. Journal Club: Kratom Cultivation Studied
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This time Dr. Jonathan Cachat and I look at a study where a team from University of Florida cultivated 68 kratom trees in a greenhouse, gave them varying levels of fertilizer, and measured for biomass, chlorophyll, and alkaloid content. Dr. Jon talks about similar studies he did with cannabis, and we go into what that …

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10. Journal Club: Kratom and Alcohol

Kratom Science
10. Journal Club: Kratom and Alcohol
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Happy Thanksgiving! The holidays after a rough year are always a great time to drink like a fish. In this episode we explore kratom and alcohol. Emerging testimony and research indicates kratom may be an effective harm reduction tool to cut down on alcohol consumption, withdrawal, and cravings. We read testimony from KratomScience.com commenters, then …

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41. Electrocution Recovery with Maxime Ruel

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41. Electrocution Recovery with Maxime Ruel
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My guest is Maxime Ruel from Quebec Canada. Max was a construction worker who was electrocuted on the job.. This led to extreme chronic pain that put him out of work. He eventually became homeless. After trying several medications he discovered kratom, which he says saved his life. This is Maxime Ruel, and this is …

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Interview with Marc Swogger, University of Rochester social scientist

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An audio version of this interview can be found here. Dr. Marc Swogger is an associate professor at the University of Rochester Medical Center, Department of Psychiatry. Dr. Swogger is a social scientist and psychologist who studies substance use. He has co-authored multiple studies on the individual and public health effects of the use of …

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