science | Kratom Science

Journal Club #25: Dopamine Response to Mitragynine in Rats

Journal Club with Dr. Jonathan Cachat

Journal Club #25: Dopamine Response to Mitragynine in Rats

00:00 / 35:37

Dr. Jon Cachat and host Brian Gallagher look at a study that examined dopamine levels with an electrochemical sensor in rats administered with various levels of mitragynine. Dopamine release was detected as significant levels after a high dose of mitragynine after 4 days. Questions explored in this episode include: Does this accurately measure the kratom …

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59. Dr. Lance McMahon, Chair of University of Florida College of Pharmacy Dept of Pharmacodynamics

Kratom Science Podcast

59. Dr. Lance McMahon, Chair of University of Florida College of Pharmacy Dept of Pharmacodynamics

00:00 / 1:02:00

Dr. Lance McMahon is Chair of the Department of Pharmacodynamics at University of Florida College of Pharmacy, a college that has been at the forefront of kratom research. Dr. McMahon studies the mechanism of action of the multiple kratom alkaloids and how they function alone and in concert on our various brain receptors. His lab …

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Journal Club #19: The FDA’s Bad Science on Kratom

Journal Club with Dr. Jonathan Cachat

Journal Club #19: The FDA's Bad Science on Kratom

00:00 / 49:47

Neuroscientist Dr. Jonathan Cachat and host Brian Gallagher look at the blistering report by Jane Babin released in August 2018: “FDA Fails to Follow the Science on Kratom” (PDF available here https://t.co/G76TVsWdLY?amp=1 ). Babin demonstrates how FDA manipulated data to create a Schedule I justification based on what a former HHS Assistant Secretary of Health …

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49. Comedian Shane Mauss Talks Science Podcasting and Kratom

Kratom Science Podcast

49. Comedian Shane Mauss Talks Science Podcasting and Kratom

00:00 / 1:12:02

Shane Mauss is a stand up comedian who has appeared on Late Night with Conan O’Brien, Jimmy Kimmel Live, The Joe Rogan Experience, WTF with Marc Maron, Comedy Central, The Green Room with Paul Provenza, and Getting Doug with High, just to name a few. For the past 7 years he’s interviewed scientists on a …

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47. Take it as a Tea with Hamilton’s Pharmacopeia Producer Soren Shade

Kratom Science Podcast

47. Take it as a Tea with Hamilton's Pharmacopeia Producer Soren Shade

00:00 / 55:21

Soren Shade grew up in the woods of West Virginia. Through a program for low-income, high-achieving students, he studied philosophy at Columbia University in New York. In his senior year he worked research assistant for Hamilton Morris and ended up as a producer on Season 3 of Hamilton’s Pharmacopeia, released earlier this year. Soren is …

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Journal Club #16: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract

Journal Club with Dr. Jonathan Cachat

Journal Club #16: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract

00:00 / 47:20

Another study from University of Florida is the “first report that has simultaneously evaluated the systemic exposure of 11 kratom alkaloids following the administration of traditional and commercial kratom products” (Kamble, 2021). Researchers looked at the pharmacokinectics (how drugs move through the body and are metabolized) of alkaloids in rat plasma following the oral administration …

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Inteview with Pharmacokineticist and Kratom Researcher Dr. Abhisheak Sharma

Leave a Comment / General, Research / By Brian

For audio of this interview as well as studies cited here see Kratom Science Podcast #45 KratomScience: You have your background in pharmacokinetics. What made you interested in going into that field? Dr. Abhisheak Sharma: So basically I did my PhD in 2015 and I moved to the States to do my post-doctoral studies with …

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Study: 7-hydroxymitragynine Metabolizes into the More Potent ‘Mitragynine Pseudoindoxyl’ in Human Plasma

Leave a Comment / General, Research / By Brian

A study out of University of Florida published in the journal ACS Pharmacology & Translational Science found that the potency of powder kratom may be due not only to the increased level of 7-hydroxymitragynine (7-HMG), but the way the 7-HMG metabolizes in human plasma (Kamble 2020). Fresh kratom consumed traditionally in Southeast Asia has been …

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44. Biomedical Educator and Research Scientist Dr. Walter Prozialeck

Kratom Science Podcast

44. Biomedical Educator and Research Scientist Dr. Walter Prozialeck

00:00 / 1:00:29

My guest is Dr. Walter Prozialeck. Originally from Johnstown, PA, Dr. Prozialeck is a biomedical educator and researcher at Midwestern University in Chicago, where he served as chair of the Department of Pharmacology from 1997 to 2018. He’s been studying kratom since 2012. We talk about one of the first research reviews published on kratom …

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Journal Club #12: Kratom Cultivation Studied

Journal Club with Dr. Jonathan Cachat

Journal Club #12: Kratom Cultivation Studied

00:00 / 33:58

This time Dr. Jonathan Cachat and I look at a study where a team from University of Florida cultivated 68 kratom trees in a greenhouse, gave them varying levels of fertilizer, and measured for biomass, chlorophyll, and alkaloid content. Dr. Jon talks about similar studies he did with cannabis, and we go into what that …

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