science

Why engaging with kratom misinformation hurts more than helps

The conversation around kratom is as complex as the plant itself. For kratom to manifest in our society as a healing plant instead of a perceived dangerous drug, the science of kratom needs to become conventional wisdom. For the millions of Americans kratom has already helped, we can’t afford to spend 80 years digging our …

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Is it a good idea to make a 7-hydroxymitragynine based drug?

A Vancouver drug company announced that it has filed a patent for a deuterated form of 7-hydroxymitragynine (7-HMG) called D7-h. The company, Nirvana Life Sciences Inc., intends to pursue D7-h as a pain relieving drug, citing 7-HMG’s partial opioid agonism, and the deuteration process that they say makes the drug last longer. A deuterated drug …

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88. Kratom News for September 2022

Kratom Science Podcast
Kratom Science Podcast
88. Kratom News for September 2022
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Kailee joins Brian to look at the latest kratom news. This month we look at an investigative report asking questions about academic freedom at University of Florida that directly affected kratom scientists, past podcast guest Oliver Grundmann and Christopher McCurdy. Kratom regulations preventing sales to minors pass Pennsylvania House. A kratom consumer protection act is …

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NIDA is rolling out a massive nationwide study of regular kratom consumers

QR Code link https://enroll.drugabuse.gov/kratom-nida/ From the research team: About The KEMA Study We are conducting a new study on kratom entitled “Real-world momentary assessment of kratom use accompanied by product assays: A natural history study toward an interdisciplinary characterization of kratom use and pharmacology”! That is a long name, so we typically refer to it …

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85. Kratom News, July 2022

Kratom Science Podcast
Kratom Science Podcast
85. Kratom News, July 2022
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Kailee joins Brian to discuss the latest in kratom legal, international, and science news for July 2022. Articles discussed in this episode: PA House passes bill banning sale of Kratom to minors https://www.wkbn.com/news/pennsylvania/pa-house-passes-bill-banning-sale-of-kratom-to-minors/ Online kratom sales okayed by [Thailand’s] House https://www.bangkokpost.com/thailand/general/2337463/online-kratom-sales-okayed-by-house Buddhist monks banned from using cannabis, except as medicine https://www.nationmultimedia.com/in-focus/40017260 “Kratom use as more …

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Journal Club #33: Kratom Scientists Pen Letter Questioning Case Report Review

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #33: Kratom Scientists Pen Letter Questioning Case Report Review
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Dr. Cachat and Brian look at a letter (Smith et al, 2022) authored by former Kratom Science Podcast guests Dr. Kirsten Smith, Dr. Oliver Grundmann, Dr. Chris McCurdy, Dr. Darshan Singh, and other experts in the kratom field. The letter questions a systematic review (Broyan et al, 2022) of kratom case reports that offers buprenorphine …

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Journal Club #27: Does Kratom Kill…E-coli and Streptococcus Pneumoniae?

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #27: Does Kratom Kill...E-coli and Streptococcus Pneumoniae?
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Spoiler alert: kinda, but its more the quercetin in kratom, which is available in many food plants and as a dietary supplement on its own. This study comes to us from a team at Universitas Nahdlatul Ulama Surabaya (UNUSA) in Surabaya, Indonesia, on the island of Java, south of the island of Kalimantan, where most …

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Interview with Dr. Lance McMahon, Chair of Dept of Pharmacodynamics, UF College of Pharmacy

Dr. Lance McMahon is Chair of the Department of Pharmacodynamics at University of Florida College of Pharmacy. Dr. McMahon is involved in pioneering kratom research that looks at the various kratom alkaloids, how they function on our brain receptors, and how that creates kratom’s complex effects on our bio. We talk about this research, where …

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Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice
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Dr. JC and Brian look at a study out of University of Science, Malaysia. The comprehensive and detailed study in mice from University of Science, Malaysia revealed mitragynine in very high doses is an agonist (binds to and activates) cannabinoid receptor Type 1 (CB1). Mice administered with high-dose mitragynine demonstrated similar reward-seeking behavior and cognitive …

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