Scientists Interview Kratom Consumers About Their Experience

Last year, we published a 255 page document of first-person experiences that kratom consumers posted in the comments section of articles. Other places like feature thousands of kratom testimonies.

So far the nuances of these experiences, though abundant and similar, have not been reflected in the science. Case reports, often woefully inadequate in information, have focused on rare kratom-related toxicities and negative experiences. Surveys of kratom consuming populations in both the US and Malaysia have been informative but by design lacking in nuance, context, and limiting in terms of telling a complex personal story.

Scientists from the National Institute on Drug Abuse (NIDA), Johns Hopkins University, and University of Florida College of Pharmacy have taken a step toward bridging the gap between the science of kratom and the real world experience of those who consume it. In an article published in Fronteirs in Pharmacology called “Examining the paradoxical effects of kratom: a narrative inquiry“scientists interview ten kratom consumers and, rather than just running a statistical analysis of answers to draw conclusions, extensive space is allowed for consumers to speak in their own words.

The researchers explain in the introduction:

Until there are controlled studies of the pharmacology and subjective effects of kratom alkaloids in humans, one of the best sources of insight on kratom-product use remains qualitative data with nuanced descriptions of kratom effects from those who use it regularly.

Excerpts from interviews with 10 kratom consumers appear in the paper, four female, six male, ranging in age from 26-60. The lowest average dose reported was 1 gram and the highest was 10 grams. Participants have been using kratom from 6 months to 8 years. Many of the participants used kratom for opioid withdrawals or alcohol use disorder, and also to deal with chronic pain. Kratom’s common effects were described, and all participants “experienced acute combination effects that were largely, even simultaneously, analgesic and stimulatory.” Many described eye wobbles as an effect of taking too much kratom, which the researchers relay as “a jittery feeling accompanied by what seemed to be nystagmus” and “a possible manifestation of serotonin syndrome”.

Researchers pointed out that about half of the participants qualified for “kratom use disorder” (KUD): 3 mild, 1 moderate, and 1 severe. KUD is not yet ensconced in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) but researchers point out here that in prior studies, KUD was “determined largely on the basis of physical tolerance and withdrawal rather than psychosocial impairment or risky use”.

Open access for this article is available so you can read the participants in their own words.

We applaud the continued effort by scientists in their ongoing kratom research to consider the real world evidence of those who consume it, and analyze that evidence beyond what we can do here.

The researchers conclude:

Until sufficient scientific funding and manpower are harnessed to conduct human laboratory studies on kratom alkaloids, including clinical trials for some of the conditions for which people currently use kratom, we should invite people using kratom to share their expertise on kratom-induced effects via these in-depth qualitative discussions. At present, they remain the experts on this subject. This is both an indictment of the current science and a call for further investigation.


Smith, K. E., Feldman, J. D., Dunn, K. E., McCurdy, C. R., Weiss, S. T., Grundmann, O., Garcia-Romeu, A., Nichels, J., & Epstein, D. H. (2023). Examining the paradoxical effects of kratom: a narrative inquiry. Frontiers in pharmacology, 14, 1174139.

6 thoughts on “Scientists Interview Kratom Consumers About Their Experience”

  1. I was a soccer player for my high school growing up and really messed up my knee during a tournament my jr year. I practically lived on the pain meds the doctors had prescribed me and it wasn’t long before those little pills started controlling my life. I needed it to help manage the initial pain of the injury and the chronic pain that followed, but it became so much more. a friend of mine found some kratom at a local smoke shop and suggested I try it in place of my prescription to see if the pain releving properties would trick my brain. I honestly only tried it to make him happy and to my surprise, it actually worked. Not only did it help ease my pain, but it also helped with my cravings. Kratom is truly a life-saver and I will die on this hill

  2. Hey everyone! Just wanted to share my experience with kratom. I’m a college student, and I was feeling overwhelmed with stress and struggling to find balance. I came across kratom online and decided to give it a try on a whim (I did my research first). It really helped me relax and stay focused on my studies. I noticed improvements in my concentration, productivity, and my overall well-being, it even helped with physical symptoms like headaches and muscle aches. Kratom has truly been a game-changer for me, and I’m so grateful for the positive impact it’s had on my life

  3. 10 is a really small sample size but i appreciate their attempt to make it as diverse as possible given their circumstances. i do agree there is too much of a focus on the drug addiction help it can provide though instead of mentioning the myriad of other things it is known to do too. Hopefully we will see some of that come mroe into light in the future

  4. 100% agreed that the media and some of the science focuses way too much on the negative. I love qualitative data–we need a mix of qualitative and quantitative research–though 10 respondents is not a lot. I totally get the eye wobble and jittery effects…I mean it’s not a perfect comparison by any means, but you can definitely see some relation between kratom and coffee (botanically similar plants) especially in the potential for addiction. I would love to know what exactly the symptoms were in the severe KUD respondent and whether that person was a polysubstance user. Without a doubt, regular kratom users tend to experience withdrawal symptoms (again, like coffee), but the stories of people ruining their lives over kratom is far and few between, especially compared to people who have found relief and benefits from responsible use. The American Kratom Association recently made a very interesting presentation at the UN Commission on Narcotic Drugs.

  5. Great article!
    Absolutely we focus way too much on the negative.. I’ve been waiting for this for a long time actually
    If we could get a media piece that would interview people that have had their lives changed instead of focusing just on addiction as well that would be nice… I feel like we all get lumped into the category of old Drug addicts.. When 3/4 of the Consumer base are pain patients.

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