Dijon Evans is a survivor of severe chronic pain, and as past Kratom Science Podcast guest Nina Ajdin refers to her, a warrior. At 16 and working as a lifeguard, Dijon injured her leg trying to save a little boy from drowning. Doctors applied a cast too tight, and despite days of pleading, they would …
46. Surviving Decades-Long Severe Chronic Pain with Dijon Evans Read More »
In a 2020 case report, a teenage girl intentionally overdosed on 45 kratom capsules (500mg each = 22.5 grams or 4/5 ounce). After suffering from severe depression, the 15 year old obtained the capsules from her father, and swallowed them in an attempted suicide. On exam, patient complained of dry mouth, dizziness, restlessness, palpitations, nausea, …
Teenager Attempts Suicide by Swallowing 45 Kratom Capsules Read More »
Note: Nothing in this podcast or on KratomScience.com is intended to be medical advice, nor should it be taken as such. We’re not medical doctors. Please don’t listen to podcasts for advice on what you should or should not put in your body. Dr. Cachat continues answering questions from February’s r/kratom Ask Me Anything. This …
For audio of this interview as well as studies cited here see Kratom Science Podcast #45 KratomScience: You have your background in pharmacokinetics. What made you interested in going into that field? Dr. Abhisheak Sharma: So basically I did my PhD in 2015 and I moved to the States to do my post-doctoral studies with …
Inteview with Pharmacokineticist and Kratom Researcher Dr. Abhisheak Sharma Read More »
A team from the Department of Plant Biology at Michigan State University published the kratom genome, or the complete contents of genetic material in an organism. Using Rifat kratom trees grown in a greenhouse at the university, the team analyzed plant material to generate a draft assembly of mitragyna specioca for the first time. As …
Note: Nothing in this podcast or on KratomScience.com is intended to be medical advice, nor should it be taken as such. We’re not medical doctors. Please don’t listen to podcasts for advice on what you should or should not put in your body. For episode #14, Dr. Jonathan Cachat answers half of the remaining question …
A study out of University of Florida published in the journal ACS Pharmacology & Translational Science found that the potency of powder kratom may be due not only to the increased level of 7-hydroxymitragynine (7-HMG), but the way the 7-HMG metabolizes in human plasma (Kamble 2020). Fresh kratom consumed traditionally in Southeast Asia has been …
Dr. Abisheak Sharma studied pharmacy and pharmacokinetics in India before coming to the United States to research under kratom expert Dr. Bonnie Avery. He now researches kratom with Dr. Christopher McCurdy at University of Florida as part of the Translational Drug Development Core. Dr. Sharma addresses the concern with kratom and other drug interactions, improved …
45. Dr. Abisheak Sharma, Pharmacokineticist and Kratom Researcher Read More »
A research article in the journal Drug Testing and Analysis uncovered a flaw in previous examinations of kratom’s main alkaloid, mitragynine. The study, lead by University of Florida pharmacutics researcher Dr. Abisheak Sharma, stated: There is a possibility that earlier reported studies did not separate the four mitragynine diastereomers, resulting in over‐quantification of mitragynine in …
Levels of Kratom Alkaloid Mitragynine Were Likely Overestimated in Autopsies Read More »
We all know the mitragynine and 7-hydroxymitraginine act on the mu-opioid receptor. But for episode #13 of Journal Club we talk about a study that looks closely at the binding affinity of various kratom alkaloids on the plethora of opioid and adrenergic receptors in the brain. How exactly does this work? How do different alkaloids …
Journal Club #13: How Kratom Alkaloids Act on Brain Receptors Read More »
