Journal Club #7: Kratom Use and Mental Health w/ Dr. Marc Swogger and Dr. Jonathan Cachat

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #7: Kratom Use and Mental Health w/ Dr. Marc Swogger and Dr. Jonathan Cachat
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Host Brian Gallagher and Dr. Jonathan Cachat welcome Dr. Marc Swogger, social scientist and clinical psychologist at the University of Rochester Medical Center to discuss his 2018 article published in Drug and Alcohol Dependence “Kratom Use and Mental Health: A Systematic Review”. Along with co-author Zach Walsh, Dr. Swogger looked at all the literature published …

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Is Kratom a Drug?

Is kratom a drug, a medicinal herb, a dietary supplement, a “safe food”, a tea? These terms have a whole lot to do with social perception, a little to do with legal issues, and nothing to do with science. Kratom is a shrub that grows natively in Southeast Asia. Botanically, kratom comes from the Rubiaceae …

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38. Psychiatrists Overstate the Dangers of Kratom

Kratom Science Podcast
Kratom Science Podcast
38. Psychiatrists Overstate the Dangers of Kratom
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In a recent webinar, psychiatrists describe kratom as dangerous with lethal overdose and toxicity potential. Using the studies they cite, Brian Gallagher explains why the dose of mitragyinine to establish LD50 in mice is far beyond the levels consumed in leaf and even extracted kratom, and why one investigation into coroners’ reports disproved claims of …

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Journal Club #6: 1972 Animal Study Shows the Promise of Mitragynine

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #6: 1972 Animal Study Shows the Promise of Mitragynine
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Citation: Macko E, Weisbach JA, Douglas B. Some observations on the pharmacology of mitragynine. Archives Internationales de Pharmacodynamie et de Therapie. 1972 ;198(1):145-161. We discuss this study from 1972 that tested the effects of mitragynine in rats, mice, cats, dogs, and monkeys. Dr. Jon talks about the difference between now and then in pharmacology labs. …

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“Kratom addiction” used as defense in trial of Customs Officer who stole thousands from travelers

Joseph Cialone, a US Customers officer, is being charged with a felony for stealing approximately $10,000 from travelers coming into the United States in violation of 18 U.S. Code § 654. Over a period of a year, Cialone would target handbags and discreetly snatch money with a closed fist, then remove the latex glove from the …

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37. Sober October Starts Early

Kratom Science Podcast
Kratom Science Podcast
37. Sober October Starts Early
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Just me this time around. I talk about a soon-to-be-released document I’ve been working on through COVID that’s 200 pages of kratom testimonials from over 800 consumers who posted to KratomScience.com. I talk about a study on kratom and metabolism I blogged about here https://www.kratomscience.com/2020/09/22/study-shows-mitragynine-metabolizes-into-7-hydroxomitragynine/. And I talk about my own history of drinking alcohol …

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Study shows mitragynine metabolizes into 7-Hydroxymitragynine

Citation Kruegel AC, Uprety R, Grinnell SG, et al. 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects. ACS Cent Sci. 2019;5(6):992-1001. doi:10.1021/acscentsci.9b00141 Summary by KratomScience A study published in 2019 in the open access journal ACS Central Science found what may be a game changer in the pharmacology …

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Journal Club w/ Dr. Jonathan Cachat #5: Mitragynine Study in Rats Leads to Interesting Conclusions

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club w/ Dr. Jonathan Cachat #5: Mitragynine Study in Rats Leads to Interesting Conclusions
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Dr. Cachat and I talk about a study that tested rats with morphine, mitragynine, naloxone, buprenorphine, and rimonabant, and measured responses based on food-reinforcement training. The study concluded “The findings suggest that MG does not induce physiological dependence but can alleviate the physical symptoms associated with morphine withdrawal”. We talk about how the rats are …

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