A survey conducted from 2019-2020 found the majority of the 2,296 respondents with psychiatric conditions reported improvement in their condition following the consumption of kratom. On a scale of 1 to 10, 1 being “much worse” and 10 being “much better”, most people who use kratom (PWUK) who have been diagnosed with ADHD, PTSD, depression, …
People with psychiatric conditions report improvement after kratom use Read More »
Today on Journal Club, Dr. Jon Cachat look at a study in 2021 out of University of Colorado, Boulder in cooperation with Leafly that examines nearly 90,000 cannabis samples. Does Indica, Sativa, and Hybrid really mean anything in terms of psychoactive effects? Are cannabis strains labelled consistently in terms of cannabinoid and terpene content? We …
Journal Club #32: Cannabis Strains, Cannabinoids, and Terpenes Read More »
Dr. JC and Brian look at a study out of University of Science, Malaysia. The comprehensive and detailed study in mice from University of Science, Malaysia revealed mitragynine in very high doses is an agonist (binds to and activates) cannabinoid receptor Type 1 (CB1). Mice administered with high-dose mitragynine demonstrated similar reward-seeking behavior and cognitive …
Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice Read More »
A comprehensive and detailed study in mice from University of Science, Malaysia revealed mitragynine in very high doses is an agonist (binds to and activates) cannabinoid receptor Type 1 (CB1). Mice administered with high-dose mitragynine demonstrated similar reward-seeking behavior and cognitive impairment as mice administered with morphine and THC. Mice that received high-dose mitragynine, morphine, …
A pharmacologist today may regard traditional and plant medicine as primitive, and may entirely disregard thousands of years of use and thousands of modern-day testimonies of positive outcomes because it has not been through the rigors of hard science. On the other hand, the massive spread of anti-science misinformation has cast sometimes unreasonable doubt on …
Combining traditional plant medicine with modern medical technology Read More »
Another study from University of Florida is the “first report that has simultaneously evaluated the systemic exposure of 11 kratom alkaloids following the administration of traditional and commercial kratom products” (Kamble, 2021). Researchers looked at the pharmacokinectics (how drugs move through the body and are metabolized) of alkaloids in rat plasma following the oral administration …
Journal Club #16: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract Read More »
Article Citation with Link to Full Text Harun N, Johari IS, Mansor SM, Shoaib M. Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats. Psychopharmacology (Berl). 2020;237(3):855-867. doi:10.1007/s00213-019-05418-6 Summary by KratomScience Rats were studied in two separate experiments: Experiment 1: Observing withdrawal in rats given morphine vs. rats given mitragynine Three …
Suzette is an abstract artist and screenwriter. She was addicted to opiates for years, and after a couple attempts, got sober and made a profound change in her life with the help of kratom. This is Suzette Prutsok, and this is her kratom story. Suzette Prutsok’s art can be seen on Instragram @lagtime_artTwitter @SuzetteLPrutsok And …
