research

Let’s Look at the New Florida Kratom Consumer Protection Act

Florida House Bill 179, the Kratom Consumer Protection Act (KCPA) was signed into law by Governor Ron Desantis on June 2, 2023. The law explicitly prohibits the sale of kratom to those under 21 years of age. It also prohibits adulterants that make the product stronger or more toxic, a level of 7-hydroxymitragynine that exceeds …

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107. Dr. Peter Grinspoon on Cannabis Science and the Drug War

Kratom Science Podcast
Kratom Science Podcast
107. Dr. Peter Grinspoon on Cannabis Science and the Drug War
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Dr. Peter Grinspoon is an instructor at Harvard Medical School, primary care physician at Massachusetts General Hospital, and a 25-year cannabis specialist. His new book, released on 4/20/23 is called Seeing Through the Smoke: A Cannabis Specialist Untangles the Truth About Marijuana. We speak about how the science of cannabis, as well as kratom, is …

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Kratom and Hallucinations: Examining the Evidence Behind the Claims

Hallucination defined in Johns Hopkins Psychiatry Guide is “a perception without a stimulus” (2017). Kratom is not classified as a hallucinogen. Hallucinogens are defined by the National Institute on Drug Abuse (NIDA) as “drugs that alter a person’s awareness of their surroundings as well as their own thoughts and feelings” (2019). However, while the Food …

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Journal Club #40: Dr. Jon’s 2010 Zebrafish Research

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #40: Dr. Jon's 2010 Zebrafish Research
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For a special 40th episode, Dr. Jon revisits research he led out of Tulane University in 2010 on psychoactive substance effects in zebrafish. Out of 40+ published papers from this research, we look at one focusing on zebrafish symptoms when in withdrawal from ethanol, diazepam, morphine and caffeine. We also talk about living in New …

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Federal Bill Would Limit FDA Power Over Kratom

A federal bill cosponsored by Corey Booker (D-NJ) and Mike Lee (R-UT) in the Senate and Mark Pocan (D-WI) in the House would compel Congress to begin the process of regulating kratom on a national level, and protect the kratom industry and consumers against current Food and Drug Administration (FDA) restrictions. The cosponsors introduced the …

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88. Kratom News for September 2022

Kratom Science Podcast
Kratom Science Podcast
88. Kratom News for September 2022
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Kailee joins Brian to look at the latest kratom news. This month we look at an investigative report asking questions about academic freedom at University of Florida that directly affected kratom scientists, past podcast guest Oliver Grundmann and Christopher McCurdy. Kratom regulations preventing sales to minors pass Pennsylvania House. A kratom consumer protection act is …

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Study: Mitragynine does not rely on its metabolism into 7-hydroxymitragynine to produce pain relieving effects

In a new study by the team at University of Florida, scientists found that the metabolite 7-hydroxymitragynine does not account for the pain-relieving effects of its parent alkaloid, mitragynine (Berthold et al., 2021). Here we investigated the hotplate antinociception, pharmacokinetics, and tissue distribution of mitragynine and 7-hydroxymitragynine at equianalgesic oral doses in…mice to determine the …

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Journal Club #27: Does Kratom Kill…E-coli and Streptococcus Pneumoniae?

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #27: Does Kratom Kill...E-coli and Streptococcus Pneumoniae?
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Spoiler alert: kinda, but its more the quercetin in kratom, which is available in many food plants and as a dietary supplement on its own. This study comes to us from a team at Universitas Nahdlatul Ulama Surabaya (UNUSA) in Surabaya, Indonesia, on the island of Java, south of the island of Kalimantan, where most …

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Interview with Dr. Lance McMahon, Chair of Dept of Pharmacodynamics, UF College of Pharmacy

Dr. Lance McMahon is Chair of the Department of Pharmacodynamics at University of Florida College of Pharmacy. Dr. McMahon is involved in pioneering kratom research that looks at the various kratom alkaloids, how they function on our brain receptors, and how that creates kratom’s complex effects on our bio. We talk about this research, where …

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