brain – Kratom Science

Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice

Journal Club with Dr. Jonathan Cachat

Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice

00:00 / 39:13

Dr. JC and Brian look at a study out of University of Science, Malaysia. The comprehensive and detailed study in mice from University of Science, Malaysia revealed mitragynine in very high doses is an agonist (binds to and activates) cannabinoid receptor Type 1 (CB1). Mice administered with high-dose mitragynine demonstrated similar reward-seeking behavior and cognitive …

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Journal Club #18: Pineal Gland and DMT Facts and Myth

Journal Club with Dr. Jonathan Cachat

Journal Club #18: Pineal Gland and DMT Facts and Myth

00:00 / 39:53

In a departure from kratom science, Dr. Cachat and Brian look at a paper by a pioneering pharmacologist and researcher in the field of psychedelics, Dr. David E. Nichols. Dr. Nichols methodically lays out his case for why endogenous DMT produced in the pineal gland, brain, or other parts of the human body is not …

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Journal Club #14, Q&A Part 1: Kratom and Liver Enzymes, Alcohol, Pain Management, and Serotonin

Journal Club with Dr. Jonathan Cachat

Journal Club #14, Q&A Part 1: Kratom and Liver Enzymes, Alcohol, Pain Management, and Serotonin

00:00 / 34:05

Note: Nothing in this podcast or on KratomScience.com is intended to be medical advice, nor should it be taken as such. We’re not medical doctors. Please don’t listen to podcasts for advice on what you should or should not put in your body. For episode #14, Dr. Jonathan Cachat answers half of the remaining question …

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Journal Club #13: How Kratom Alkaloids Act on Brain Receptors

Journal Club with Dr. Jonathan Cachat

Journal Club #13: How Kratom Alkaloids Act on Brain Receptors

00:00 / 39:13

We all know the mitragynine and 7-hydroxymitraginine act on the mu-opioid receptor. But for episode #13 of Journal Club we talk about a study that looks closely at the binding affinity of various kratom alkaloids on the plethora of opioid and adrenergic receptors in the brain. How exactly does this work? How do different alkaloids …

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44. Biomedical Educator and Research Scientist Dr. Walter Prozialeck

Kratom Science Podcast

44. Biomedical Educator and Research Scientist Dr. Walter Prozialeck

00:00 / 1:00:29

My guest is Dr. Walter Prozialeck. Originally from Johnstown, PA, Dr. Prozialeck is a biomedical educator and researcher at Midwestern University in Chicago, where he served as chair of the Department of Pharmacology from 1997 to 2018. He’s been studying kratom since 2012. We talk about one of the first research reviews published on kratom …

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41. Electrocution Recovery with Maxime Ruel

Kratom Science Podcast

41. Electrocution Recovery with Maxime Ruel

00:00 / 32:04

My guest is Maxime Ruel from Quebec Canada. Max was a construction worker who was electrocuted on the job.. This led to extreme chronic pain that put him out of work. He eventually became homeless. After trying several medications he discovered kratom, which he says saved his life. This is Maxime Ruel, and this is …

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Journal Club with Dr Jonathan Cachat #3: Kratom Addiction, Listener Mail, and Elephants on LSD

Journal Club with Dr. Jonathan Cachat

Journal Club with Dr Jonathan Cachat #3: Kratom Addiction, Listener Mail, and Elephants on LSD

00:00 / 1:00:17

Dr. Jon Cachat and I talk about the article “Kratom instrumentalization for severe pain self-treatment resulting in addiction – A case report of acute and chronic subjective effects” – This is an open access article that you can read for free https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378692/ Müller, E., Hillemacher, T., & Müller, C. P. (2020). Kratom instrumentalization for severe …

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Journal Club with Dr. Jonathan Cachat #2: “The Potential for Kratom as an Antidepressant and Antipsychotic”

Journal Club with Dr. Jonathan Cachat

Journal Club with Dr. Jonathan Cachat #2: "The Potential for Kratom as an Antidepressant and Antipsychotic"

00:00 / 48:17

This is the Kratom Science Journal Club with Dr. Jonathan Cachat, neuroscientist and expert in psychopharmacology. In each episode we discuss an article in a peer reviewed journal. For episode 2 we discuss the article, “The Potential for Kratom as an Antidepressant and Antipsychotic” published in Yale Journal of Biology and Medicine, edition 93, June …

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