Last week we told you about a study published in September 2021 that showed cognitive impairment in high-dose mitragynine (MG), the main alkaloid in kratom. The study was also the subject of Kratom Science Journal Club #26. Researchers discovered that very high doses of MG, like THC and morphine, attach to CB1 receptors and cause …
Soren Shade visits Brian in Pittsburgh bearing gifts: mature kratom leaves and a kratom plant the Top Tree Herbs greenhouse in West Virginia. This is the 2nd time the Hamilton’s Pharmacopeia producer and kratom entrepreneur has been on the podcast – the first time being #47. Brian chews kratom for the first time, and we …
Dr. Lance McMahon is Chair of the Department of Pharmacodynamics at University of Florida College of Pharmacy. Dr. McMahon is involved in pioneering kratom research that looks at the various kratom alkaloids, how they function on our brain receptors, and how that creates kratom’s complex effects on our bio. We talk about this research, where …
Dr. JC and Brian look at a study out of University of Science, Malaysia. The comprehensive and detailed study in mice from University of Science, Malaysia revealed mitragynine in very high doses is an agonist (binds to and activates) cannabinoid receptor Type 1 (CB1). Mice administered with high-dose mitragynine demonstrated similar reward-seeking behavior and cognitive …
Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice Read More »
A comprehensive and detailed study in mice from University of Science, Malaysia revealed mitragynine in very high doses is an agonist (binds to and activates) cannabinoid receptor Type 1 (CB1). Mice administered with high-dose mitragynine demonstrated similar reward-seeking behavior and cognitive impairment as mice administered with morphine and THC. Mice that received high-dose mitragynine, morphine, …
Dr. Fabian Pitter Steinmetz is a senior toxicologist from Germany and an outspoken advocate for harm reduction and science-based, rational drug policy. On October 11, 2021, representing the European Coalition for Just and Effective Drug Policies, Dr. Steinmetz testified against kratom prohibition for the World Health Organization’s 44th Expert Committee on Drug Dependence . Dr. …
62. Dr. Fabian Pitter Steinmetz, Toxicologist Who Testified at the WHO Hearing on Kratom Read More »
Dr. Jon Cachat and host Brian Gallagher look at a study that examined dopamine levels with an electrochemical sensor in rats administered with various levels of mitragynine. Dopamine release was detected as significant levels after a high dose of mitragynine after 4 days. Questions explored in this episode include: Does this accurately measure the kratom …
Journal Club #25: Dopamine Response to Mitragynine in Rats Read More »
PSYCHOACTIVE with Ethan Nadelmann https://cms.megaphone.fm/channel/psychoactive?selected=HSW1919502170My guest is one of the major critics of the War on Drugs and an advocate for science-based harm reduction policy. He is founder of the Drug Policy Alliance, an organization that’s been instrumental in marijuana legalization, and helped solicit comments for the 2016 fight to keep kratom legal, among other …
61. Ethan Nadelmann, Drug Policy Alliance Founder and Host of “PSYCHOACTIVE” Read More »
Mr. Boston, who chooses to remain anonymous, was pushed out of a tree at the age of 13 where he got a slipped disk and went on a regimen of gradually stronger and stronger opioids. Living with chronic pain, he later developed an even more painful autoimmune disorder, which he says feels like being attacked …
Dr. Lance McMahon is Chair of the Department of Pharmacodynamics at University of Florida College of Pharmacy, a college that has been at the forefront of kratom research. Dr. McMahon studies the mechanism of action of the multiple kratom alkaloids and how they function alone and in concert on our various brain receptors. His lab …
