mice

Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice
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Dr. JC and Brian look at a study out of University of Science, Malaysia. The comprehensive and detailed study in mice from University of Science, Malaysia revealed mitragynine in very high doses is an agonist (binds to and activates) cannabinoid receptor Type 1 (CB1). Mice administered with high-dose mitragynine demonstrated similar reward-seeking behavior and cognitive …

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Study: High-Dose Mitragynine Interacts with Cannabinoid Receptor to Impair Cognitive Functioning

A comprehensive and detailed study in mice from University of Science, Malaysia revealed mitragynine in very high doses is an agonist (binds to and activates) cannabinoid receptor Type 1 (CB1). Mice administered with high-dose mitragynine demonstrated similar reward-seeking behavior and cognitive impairment as mice administered with morphine and THC. Mice that received high-dose mitragynine, morphine, …

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Journal Club #10: Kratom and Alcohol

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #10: Kratom and Alcohol
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Happy Thanksgiving! The holidays after a rough year are always a great time to drink like a fish. In this episode we explore kratom and alcohol. Emerging testimony and research indicates kratom may be an effective harm reduction tool to cut down on alcohol consumption, withdrawal, and cravings. We read testimony from KratomScience.com commenters, then …

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Journal Club #8: Kratom Tea for Opioid Dependence in Mice

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #8: Kratom Tea for Opioid Dependence in Mice
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This week we look at a study by a team from University of Florida called “Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence”. The science is catching up with what thousands of kratom consumers are saying — that kratom can be a safe and effective harm reduction tool for opioid withdrawal and dependence. …

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Journal Club #6: 1972 Animal Study Shows the Promise of Mitragynine

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #6: 1972 Animal Study Shows the Promise of Mitragynine
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Citation: Macko E, Weisbach JA, Douglas B. Some observations on the pharmacology of mitragynine. Archives Internationales de Pharmacodynamie et de Therapie. 1972 ;198(1):145-161. We discuss this study from 1972 that tested the effects of mitragynine in rats, mice, cats, dogs, and monkeys. Dr. Jon talks about the difference between now and then in pharmacology labs. …

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