Journal Club #6: 1972 Animal Study Shows the Promise of Mitragynine

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #6: 1972 Animal Study Shows the Promise of Mitragynine
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Citation: Macko E, Weisbach JA, Douglas B. Some observations on the pharmacology of mitragynine. Archives Internationales de Pharmacodynamie et de Therapie. 1972 ;198(1):145-161. We discuss this study from 1972 that tested the effects of mitragynine in rats, mice, cats, dogs, and monkeys. Dr. Jon talks about the difference between now and then in pharmacology labs. …

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“Kratom addiction” used as defense in trial of Customs Officer who stole thousands from travelers

Joseph Cialone, a US Customers officer, is being charged with a felony for stealing approximately $10,000 from travelers coming into the United States in violation of 18 U.S. Code § 654. Over a period of a year, Cialone would target handbags and discreetly snatch money with a closed fist, then remove the latex glove from the …

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37. Sober October Starts Early

Kratom Science Podcast
Kratom Science Podcast
37. Sober October Starts Early
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Just me this time around. I talk about a soon-to-be-released document I’ve been working on through COVID that’s 200 pages of kratom testimonials from over 800 consumers who posted to KratomScience.com. I talk about a study on kratom and metabolism I blogged about here https://www.kratomscience.com/2020/09/22/study-shows-mitragynine-metabolizes-into-7-hydroxomitragynine/. And I talk about my own history of drinking alcohol …

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Study shows mitragynine metabolizes into 7-Hydroxymitragynine

Citation Kruegel AC, Uprety R, Grinnell SG, et al. 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects. ACS Cent Sci. 2019;5(6):992-1001. doi:10.1021/acscentsci.9b00141 Summary by KratomScience A study published in 2019 in the open access journal ACS Central Science found what may be a game changer in the pharmacology …

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Journal Club w/ Dr. Jonathan Cachat #5: Mitragynine Study in Rats Leads to Interesting Conclusions

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club w/ Dr. Jonathan Cachat #5: Mitragynine Study in Rats Leads to Interesting Conclusions
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Dr. Cachat and I talk about a study that tested rats with morphine, mitragynine, naloxone, buprenorphine, and rimonabant, and measured responses based on food-reinforcement training. The study concluded “The findings suggest that MG does not induce physiological dependence but can alleviate the physical symptoms associated with morphine withdrawal”. We talk about how the rats are …

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36. Surviving Abuse and Addiction with Julie Current

Kratom Science Podcast
Kratom Science Podcast
36. Surviving Abuse and Addiction with Julie Current
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Julie Current is a survivor. She had a rough childhood and as an adult she survived physical abuse that led to multiple disabilities like PTSD, chronic pain, and epilepsy. With kratom, kava, and cannabis as tools, she’s coming up on two years sober on October 28. This is Julie Current and this is her kratom …

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Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine

Article Citation with Link to Full Text Harun N, Johari IS, Mansor SM, Shoaib M. Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats. Psychopharmacology (Berl). 2020;237(3):855-867. doi:10.1007/s00213-019-05418-6 Summary by KratomScience Rats were studied in two separate experiments: Experiment 1: Observing withdrawal in rats given morphine vs. rats given mitragynine Three …

Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine Read More »

35. Kratom in the Workplace with Michael McCunney

Kratom Science Podcast
Kratom Science Podcast
35. Kratom in the Workplace with Michael McCunney
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Working in a competitive environment in the sales and marketing field, my guest Michael McCunney uses kratom as a stimulant, cognitive boost, and for general well-being. We talk about the importance of doing research, finding a good source, discovering your dose, and staying hydrated. Music: Risey, “Memories of Thailand” The Kratom Science Podcast is produced …

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Journal Club w/ Dr. Jonathan Cachat #4: Human Evolution and Psychoactive Plants, Scratching the Surface of Kratom History, and Kratom Alkaloids

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club w/ Dr. Jonathan Cachat #4: Human Evolution and Psychoactive Plants, Scratching the Surface of Kratom History, and Kratom Alkaloids
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This episode, Dr. Jon and I use the journal article “Following the Roots of Kratom” published in 2015 by BioMed Research International as a jumping off point to talk about kratom history, human evolution and psychoactive plants, Terence McKenna’s “Stoned Ape” theory, and drug in religious cults . Plus, we answer listener mail about kratom …

Journal Club w/ Dr. Jonathan Cachat #4: Human Evolution and Psychoactive Plants, Scratching the Surface of Kratom History, and Kratom Alkaloids Read More »

34. Rod The Steelworker Switches to Kratom From Norco for Chronic Pain

Kratom Science
Kratom Science
34. Rod The Steelworker Switches to Kratom From Norco for Chronic Pain
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Rod the Steelerworker is from Michigan and has been a steelworker for 24 years. As a young man his hobbies were skateboarding and 4-wheeling. As a result of those hobbies, a career doing repetitive physical labor, along with Degenerative Disk Disease, diverticulitis, and IBS, he suffers from chronic pain. A prescription to Norco led him …

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