opioid

DEA to Cut Opioid Supply; Now Accepting Public Comments

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The Drug Enforcement Administration (DEA) is threatening to cut the supply of opioids at a time when pain patients are struggling to access treatment, and illicit opioids are becoming more potent. The DEA is receiving public comments on the proposed cuts at this link:  https://www.regulations.gov/document/DEA-2023-0150-0001 . Comments are due by December 4, 2023. The Controlled …

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Scientists review kratom-related toxic events

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Kratom has been consumed for at least four centuries in Southeast Asia, and likely longer. Southeast Asian drug policy expert Pascal Tanguay told Kratom Science about the earliest documented evidence he’s seen: “Kratom was referred to as a medicinal herb in Thai pharmacopeias dating from the 1650s, as was indicated for the treatment of stomach …

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Journal Club #36: Mitragynine for Chemotherapy-Induced Pain

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #36: Mitragynine for Chemotherapy-Induced Pain
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Dr. Jon and Brian look at a study (Farkas et al., 2022 https://doi.org/10.1016/j.ibneur.2022.08.007) in mice out of Temple University exploring whether mitragynine can help attenuate chemotherapy-induced peripheral neuropathic (CIPN). The team used oxaliplatin, a chemotherapy drug, to induce this condition in an equal number of male and female mice. Mitragynine was also combined with four …

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Interview with Dr. Oliver Grundmann, Professor of Medicinal Chemistry and Kratom Researcher, University of Florida

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An audio version of this interview can be found on the Kratom Science Podcast #40 Kratom Science: How did you become involved with studying kratom? Oliver Grundmann: It’s an interesting way, how I got involved with kratom. In 2015 one of my Masters students who works in the forensic field with a forensic toxicology lab …

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List of “New” Psychoactive Substances of Natural Origin

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Note: This article is a summary of the journal article cited as follows:Gonçalves, J., Luís, Â., Gallardo, E., & Duarte, A. P. (2021). Psychoactive Substances of Natural Origin: Toxicological Aspects, Therapeutic Properties and Analysis in Biological Samples. Molecules (Basel, Switzerland), 26(5), 1397. https://doi.org/10.3390/molecules26051397Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961374/ Scientists from Portugal, where the possession and consumption of all …

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Journal Club #8: Kratom Tea for Opioid Dependence in Mice

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #8: Kratom Tea for Opioid Dependence in Mice
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This week we look at a study by a team from University of Florida called “Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence”. The science is catching up with what thousands of kratom consumers are saying — that kratom can be a safe and effective harm reduction tool for opioid withdrawal and dependence. …

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30. Dr. Darshan Singh, University of Science in Malaysia

Kratom Science Podcast
Kratom Science Podcast
30. Dr. Darshan Singh, University of Science in Malaysia
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My guest is Dr. Darshan Singh from the Center for Drug Research at the University of Science in Malaysia. Dr. Singh studies substance abuse, addiction treatment, and harm reduction. He has conducted multiple studies of kratom consumers, and has found kratom in its pure form to be a safe and effective way to decrease substance …

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2. A Life of Chaos Turned Stable with Nick Clark

Kratom Science Podcast
Kratom Science Podcast
2. A Life of Chaos Turned Stable with Nick Clark
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For more information on all things kratom visit kratomscience.com Nick Clark was addicted to opiates and homeless by the age of 17. His father was a crack addict, and his girlfriend (now wife) shared his opiate addiction. Nick Clark’s military career didn’t end well, but he says he’s earned a “Junkie Badge of Honor” for …

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