endocannabinoid

Study: High-Dose Mitragynine Interacts with Cannabinoid Receptor to Impair Cognitive Functioning

Leave a Comment / General / By Brian

A comprehensive and detailed study in mice from University of Science, Malaysia revealed mitragynine in very high doses is an agonist (binds to and activates) cannabinoid receptor Type 1 (CB1). Mice administered with high-dose mitragynine demonstrated similar reward-seeking behavior and cognitive impairment as mice administered with morphine and THC. Mice that received high-dose mitragynine, morphine, …

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Meet the Mother of All Cannabinoids: CBG

Leave a Comment / General, Research / By Andrew

What is CBG? Many have heard about CBD, but are you familiar with CBG? Yeah, you read that right, CBG, or in long-form, Cannabigerolic acid (CBGA), is an all-essential aspect of any cannabis plant. A cannabinoid in it’s own right, CBGA serves as the mother to all other cannabinoids. Meaning, CBGA is the very first …

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Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine

Leave a Comment / Research / By Brian

Article Citation with Link to Full Text Harun N, Johari IS, Mansor SM, Shoaib M. Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats. Psychopharmacology (Berl). 2020;237(3):855-867. doi:10.1007/s00213-019-05418-6 Summary by KratomScience Rats were studied in two separate experiments: Experiment 1: Observing withdrawal in rats given morphine vs. rats given mitragynine Three …

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