mitragynine

Scientists find “insufficient evidence to suggest that kratom causes seizures”

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Note: There is a correlation between kratom and seizures, but causation has not been established. Kratom alone or kratom combined with other substances could very well cause seizures in some consumers, but as this study shows, there is not enough evidence to determine causation. Seizures have been commonly listed as a side effect of kratom …

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Scientists Test 7-OH Products Marketed as ‘Kratom Extracts’

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Scientists from British Columbia Institute of Technology and University of Illinois published a study that examines five 7-hydroxymitragynine (the abbreviation 7-OH has become popularized, but the scientists use 7-HMG in this study) products marketed as “kratom extracts”. A kratom extract is a concentrated form of the kratom plant made by extracting its active alkaloids, of …

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Study: Kratom alkaloid make-up dependent on genetics, environmental factors, and processing

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A new study published in Frontiers in Plant Science is presenting a clearer picture of how post-harvest processing changes the plant’s chemistry. The researchers from University of Florida and Oregon State University compared kratom varieties grown in Hawaii and Malaysia to see how factors like withering time, drying temperature, and harvest season influence alkaloid profiles—particularly …

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Review Finds Insufficient Evidence of Severe Health Risks From Kratom Alone

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Important to note: This does NOT mean severe health risks from kratom alone do not exist. There is a toxic amount of any substance that can be ingested, including kratom. The majority, but not all, of toxic adverse events associated with kratom have involved other substances, as well as substance misuse in general. Kratom should …

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Dr. McCurdy at Kratom Debate: Natural Leaf is “the only product that should be in the marketplace”

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The kratom industry is railing against 7-OH products as problematic, but are extra-strength kratom extracts problematic too? The controversy surrounding the rise of new 7-hydroxymitragynine (7-OH) products has sparked a debate among various players in the kratom industry, as well as scientists and consumers. A debate called “The 7-OH Fault Line” took place at the …

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AKA and HART Face Off Over 7-Hydroxymitragynine This Friday

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Members of the American Kratom Association (AKA) and the Holistic Alternative Recovery Trust (HART) will debate the controversial alkaloid 7-hydroxymitragynine (7-OH) and the 7-OH-abundant products that have become available to consumers in the past 2 years. Billed as “The 7-OH Fault Line”, the debate will take place at the Las Vegas Convention Center 3150 Paradise …

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Study Shows Kratom Leaves Attacked by Insects Have Higher Mitragynine

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Read the full study, where the above image can be found: https://pmc.ncbi.nlm.nih.gov/articles/PMC12040156 Researchers at Kasetsart University and Chulalongkorn University in Bangkok, Thailand found that when insects like beetles, butterflies, and true bugs feed on kratom, the plant produces more mitragynine as a defense mechanism. This increase is also linked to higher leaf acidity. Plants produce …

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Johns Hopkins Seeks Participants for Online Study on 7-OH Kratom Products

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The Johns Hopkins University School of Medicine is conducting a groundbreaking online study on 7-hydroxymitragynine (7-OH), a compound associated with certain kratom products. The study invites individuals who have consumed 7-OH products to participate by completing a screening process and, if eligible, an online survey about their usage patterns. As a thank-you, participants who complete …

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Isolated 7-hydroxymitragynine Now Being Sold in Tablets and Liquid Shots

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Companies are now selling isolated 7-hydroxymitragyinine in a grey marketplace that the Food and Drug Administration (FDA) refuses to regulate. Found in near-zero amounts in plain leaf kratom, 7-hydroxymitragyinine has been shown in animal studies to have enormous dependency potential. Obeng et al 2020 demonstrated that while mitragynine, kratom’s most abundant alkaloid, has “a complex …

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Journal Club #38: Mitragynine in Kratom Trees in Thailand

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #38: Mitragynine in Kratom Trees in Thailand
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Thailand has recently decriminalized kratom after 79 years of prohibition. In today’s episode of Kratom Science Journal Club, Dr. Cachat and Brian look at a study funded in part by the Thai government that analyzed kratom trees growing in various regions of Thailand. The team measured mitragynine levels, accounting for variables in climate such as …

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