mitragynine – Page 2 – Kratom Science

Study: High-Dose Mitragynine Interacts with Cannabinoid Receptor to Impair Cognitive Functioning

Journal Club #25: Dopamine Response to Mitragynine in Rats

Journal Club with Dr. Jonathan Cachat

Journal Club #25: Dopamine Response to Mitragynine in Rats

00:00 / 35:37

Dr. Jon Cachat and host Brian Gallagher look at a study that examined dopamine levels with an electrochemical sensor in rats administered with various levels of mitragynine. Dopamine release was detected as significant levels after a high dose of mitragynine after 4 days. Questions explored in this episode include: Does this accurately measure the kratom …

Journal Club #25: Dopamine Response to Mitragynine in Rats Read More »

59. Dr. Lance McMahon, Chair of University of Florida College of Pharmacy Dept of Pharmacodynamics

Kratom Science Podcast

59. Dr. Lance McMahon, Chair of University of Florida College of Pharmacy Dept of Pharmacodynamics

00:00 / 1:02:00

Dr. Lance McMahon is Chair of the Department of Pharmacodynamics at University of Florida College of Pharmacy, a college that has been at the forefront of kratom research. Dr. McMahon studies the mechanism of action of the multiple kratom alkaloids and how they function alone and in concert on our various brain receptors. His lab …

59. Dr. Lance McMahon, Chair of University of Florida College of Pharmacy Dept of Pharmacodynamics Read More »

53. Journalist Nick Wing on Covering Kratom

Kratom Science Podcast

53. Journalist Nick Wing on Covering Kratom

00:00 / 49:12

Nick Wing is currently editor of the nonprofit journal The Appeal (theappeal.org). He spent nearly 10 years as a journalist for Huffington Post, where he did extensive in-depth reporting on kratom, starting in 2016. In the course of his work, Nick Wing discovered that one of FDA’s “kratom-related deaths” was a man who died of …

53. Journalist Nick Wing on Covering Kratom Read More »

Hamilton Morris, Soren Shade, and Dr. Oliver Grundmann Talk Kratom and a New Survey

Kratom Science Podcast

Hamilton Morris, Soren Shade, and Dr. Oliver Grundmann Talk Kratom and a New Survey

00:00 / 1:03:19

Take the new anonymous kratom survey! tinyurl.com/kratomteasurvey Hamilton Morris, creator of Hamilton’s Pharmacopeia, and producer Soren Shade talk to University of Florida scientist and past Kratom Science Podcast guest Dr. Oliver Grundmann about his new anonymous research survey on kratom tea. All kratom consumers are invited to participate. Plus, how an overly positive kratom narrative …

Hamilton Morris, Soren Shade, and Dr. Oliver Grundmann Talk Kratom and a New Survey Read More »

Study: 7-hydroxymitragynine Metabolizes into the More Potent ‘Mitragynine Pseudoindoxyl’ in Human Plasma

Leave a Comment / General, Research / By Brian

A study out of University of Florida published in the journal ACS Pharmacology & Translational Science found that the potency of powder kratom may be due not only to the increased level of 7-hydroxymitragynine (7-HMG), but the way the 7-HMG metabolizes in human plasma (Kamble 2020). Fresh kratom consumed traditionally in Southeast Asia has been …

Study: 7-hydroxymitragynine Metabolizes into the More Potent ‘Mitragynine Pseudoindoxyl’ in Human Plasma Read More »

45. Dr. Abisheak Sharma, Pharmacokineticist and Kratom Researcher

Kratom Science Podcast

45. Dr. Abisheak Sharma, Pharmacokineticist and Kratom Researcher

00:00 / 45:29

Dr. Abisheak Sharma studied pharmacy and pharmacokinetics in India before coming to the United States to research under kratom expert Dr. Bonnie Avery. He now researches kratom with Dr. Christopher McCurdy at University of Florida as part of the Translational Drug Development Core. Dr. Sharma addresses the concern with kratom and other drug interactions, improved …

45. Dr. Abisheak Sharma, Pharmacokineticist and Kratom Researcher Read More »

Levels of Kratom Alkaloid Mitragynine Were Likely Overestimated in Autopsies

Leave a Comment / General, Research / By Brian

A research article in the journal Drug Testing and Analysis uncovered a flaw in previous examinations of kratom’s main alkaloid, mitragynine. The study, lead by University of Florida pharmacutics researcher Dr. Abisheak Sharma, stated: There is a possibility that earlier reported studies did not separate the four mitragynine diastereomers, resulting in over‐quantification of mitragynine in …

Levels of Kratom Alkaloid Mitragynine Were Likely Overestimated in Autopsies Read More »

Full Text of 2018 HHS Letter to DEA Rescinding Kratom Ban Recommendation

Leave a Comment / Current Events, General, News / By Brian

DEPARTMENT OF HEALTH AND HUMAN SERVICESOffice of the SecretaryOffice of the Assistant Secretary for HealthWashington, D.C. 20201 AUG 16 2018 [stamped] The Honorable Uttam DhillonActing AdministratorDrug Enforcement AdministrationU.S. Department of Justice8701 Morrissette DriveSpringfield, VA 22152 Dear Mr. Dhillon: Pursuant to the Controlled Substances Act (CSA), 21 U.S.C. § 811, I am rescinding our prior recommendation …

Full Text of 2018 HHS Letter to DEA Rescinding Kratom Ban Recommendation Read More »

Journal Club #10: Kratom and Alcohol

Journal Club with Dr. Jonathan Cachat

Journal Club #10: Kratom and Alcohol

00:00 / 38:25

Happy Thanksgiving! The holidays after a rough year are always a great time to drink like a fish. In this episode we explore kratom and alcohol. Emerging testimony and research indicates kratom may be an effective harm reduction tool to cut down on alcohol consumption, withdrawal, and cravings. We read testimony from KratomScience.com commenters, then …

Journal Club #10: Kratom and Alcohol Read More »