10. Journal Club: Kratom and Alcohol

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Happy Thanksgiving! The holidays after a rough year are always a great time to drink like a fish. In this episode we explore kratom and alcohol. Emerging testimony and research…

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Is Kratom a Drug?
1950s ad for methedrine, aka legal methamphetamine

Is Kratom a Drug?

Is kratom a drug, a medicinal herb, a dietary supplement, a "safe food", a tea? These terms have a whole lot to do with social perception, a little to do…

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38. Psychiatrists Overstate the Dangers of Kratom

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In a recent webinar, psychiatrists describe kratom as dangerous with lethal overdose and toxicity potential. Using the studies they cite, Brian Gallagher explains why the dose of mitragyinine to establish…

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Toxic Levels of Kratom and LD50 of Mitragynine
By User:Ring0 - Own work, Public Domain, https://commons.wikimedia.org/w/index.php?curid=831924

Toxic Levels of Kratom and LD50 of Mitragynine

Mitragynine is the most abundant alkaloid in kratom. Kratom contains about 40 alkaloids that we know of. All of the alkaloids combined make up only 0.5-1.5% of the total leaf…

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6. Journal Club with Dr. Jonathan Cachat – 1972 Animal Study Shows the Promise of Mitragynine

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Citation: Macko E, Weisbach JA, Douglas B. Some observations on the pharmacology of mitragynine. Archives Internationales de Pharmacodynamie et de Therapie. 1972 ;198(1):145-161. We discuss this study from 1972 that…

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37. Sober October Starts Early

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Just me this time around. I talk about a soon-to-be-released document I've been working on through COVID that's 200 pages of kratom testimonials from over 800 consumers who posted to…

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5. Journal Club with Dr. Jonathan Cachat – Mitragynine Study in Rats Leads to Interesting Conclusions

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Dr. Cachat and I talk about a study that tested rats with morphine, mitragynine, naloxone, buprenorphine, and rimonabant, and measured responses based on food-reinforcement training. The study concluded "The findings…

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Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine
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Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine

Article Citation with Link to Full Text Harun N, Johari IS, Mansor SM, Shoaib M. Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats. Psychopharmacology (Berl).…

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