mitragynine

81. Dr. Kirsten Smith of NIDA Returns

Kratom Science Podcast
Kratom Science Podcast
81. Dr. Kirsten Smith of NIDA Returns
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Dr. Kirsten Smith of National Institute on Drug Abuse (NIDA) joins us once again to talk about an upcoming comprehensive study that will include a detailed nationwide survey, testing of kratom samples, and testing select individual kratom consumers. We also cover several papers that Dr. Smith led or co-authored that have been published since her …

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Journal Club #28: Mitragynine Does Not Rely on 7-hydroxymitragynine for Pain Relief Effects

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #28: Mitragynine Does Not Rely on 7-hydroxymitragynine for Pain Relief Effects
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Dr. Cachat and host Brian Gallagher look at a groundbreaking study from University of Florida School of Pharmacy showing mitragynine has pain relieving effects independent of its metabolism into 7-hydroxymitragynine. This could be revolutionary in the study of kratom as a safer pain medicine. We go on to talk about the cannabis testing lab that …

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69. Dr. Christopher McCurdy and Dr. Brian Pearson on the Future of Kratom

Kratom Science Podcast
Kratom Science Podcast
69. Dr. Christopher McCurdy and Dr. Brian Pearson on the Future of Kratom
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Dr. Chris McCurdy is a medicinal chemist who has done groundbreaking research on kratom since 2004, starting at the University of Mississippi. In 2017 Dr. McCurdy moved to the University of Florida College of Pharmacy where he continues his research today with an expert team of pharmacologists, unlocking the function of kratom’s many alkaloids and …

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Study: Mitragynine does not rely on its metabolism into 7-hydroxymitragynine to produce pain relieving effects

In a new study by the team at University of Florida, scientists found that the metabolite 7-hydroxymitragynine does not account for the pain-relieving effects of its parent alkaloid, mitragynine (Berthold et al., 2021). Here we investigated the hotplate antinociception, pharmacokinetics, and tissue distribution of mitragynine and 7-hydroxymitragynine at equianalgesic oral doses in…mice to determine the …

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Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice
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Dr. JC and Brian look at a study out of University of Science, Malaysia. The comprehensive and detailed study in mice from University of Science, Malaysia revealed mitragynine in very high doses is an agonist (binds to and activates) cannabinoid receptor Type 1 (CB1). Mice administered with high-dose mitragynine demonstrated similar reward-seeking behavior and cognitive …

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Study: High-Dose Mitragynine Interacts with Cannabinoid Receptor to Impair Cognitive Functioning

A comprehensive and detailed study in mice from University of Science, Malaysia revealed mitragynine in very high doses is an agonist (binds to and activates) cannabinoid receptor Type 1 (CB1). Mice administered with high-dose mitragynine demonstrated similar reward-seeking behavior and cognitive impairment as mice administered with morphine and THC. Mice that received high-dose mitragynine, morphine, …

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Journal Club #25: Dopamine Response to Mitragynine in Rats

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #25: Dopamine Response to Mitragynine in Rats
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Dr. Jon Cachat and host Brian Gallagher look at a study that examined dopamine levels with an electrochemical sensor in rats administered with various levels of mitragynine. Dopamine release was detected as significant levels after a high dose of mitragynine after 4 days. Questions explored in this episode include: Does this accurately measure the kratom …

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59. Dr. Lance McMahon, Chair of University of Florida College of Pharmacy Dept of Pharmacodynamics

Kratom Science Podcast
Kratom Science Podcast
59. Dr. Lance McMahon, Chair of University of Florida College of Pharmacy Dept of Pharmacodynamics
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Dr. Lance McMahon is Chair of the Department of Pharmacodynamics at University of Florida College of Pharmacy, a college that has been at the forefront of kratom research. Dr. McMahon studies the mechanism of action of the multiple kratom alkaloids and how they function alone and in concert on our various brain receptors. His lab …

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53. Journalist Nick Wing on Covering Kratom

Kratom Science Podcast
Kratom Science Podcast
53. Journalist Nick Wing on Covering Kratom
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Nick Wing is currently editor of the nonprofit journal The Appeal (theappeal.org). He spent nearly 10 years as a journalist for Huffington Post, where he did extensive in-depth reporting on kratom, starting in 2016. In the course of his work, Nick Wing discovered that one of FDA’s “kratom-related deaths” was a man who died of …

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Hamilton Morris, Soren Shade, and Dr. Oliver Grundmann Talk Kratom and a New Survey

Kratom Science Podcast
Kratom Science Podcast
Hamilton Morris, Soren Shade, and Dr. Oliver Grundmann Talk Kratom and a New Survey
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Take the new anonymous kratom survey! tinyurl.com/kratomteasurvey Hamilton Morris, creator of Hamilton’s Pharmacopeia, and producer Soren Shade talk to University of Florida scientist and past Kratom Science Podcast guest Dr. Oliver Grundmann about his new anonymous research survey on kratom tea. All kratom consumers are invited to participate. Plus, how an overly positive kratom narrative …

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