Disclaimer: Preclinical studies on compounds’ effects on test animals do not always demonstrate exactly how compounds will affect humans A new study in rats examined the respiratory effects of mitragyinine (MG), considered the main compound in most kratom leaves consumed by users, and 7-hydroxymitragyinine (7-HMG) that occurs in very trace amounts in dried kratom leaf …
Health Claims in Texas Smoke Shops With a dearth of regulation and market enforcement, marketers of kratom, kratom-derived synthetics, and products like hemp and THC continue to employ shady business practices to sell their products. Researchers from university pharmacy and medicine departments conducted a secret shopper investigation at 100 smoke shops in San Antonio and …
Nefarious Marketing: Making Health Claims and Synthetics Sold as “Kratom” Read More »
Read the full study, where the above image can be found: https://pmc.ncbi.nlm.nih.gov/articles/PMC12040156 Researchers at Kasetsart University and Chulalongkorn University in Bangkok, Thailand found that when insects like beetles, butterflies, and true bugs feed on kratom, the plant produces more mitragynine as a defense mechanism. This increase is also linked to higher leaf acidity. Plants produce …
Study Shows Kratom Leaves Attacked by Insects Have Higher Mitragynine Read More »
The Johns Hopkins University School of Medicine is conducting a groundbreaking online study on 7-hydroxymitragynine (7-OH), a compound associated with certain kratom products. The study invites individuals who have consumed 7-OH products to participate by completing a screening process and, if eligible, an online survey about their usage patterns. As a thank-you, participants who complete …
Johns Hopkins Seeks Participants for Online Study on 7-OH Kratom Products Read More »
tinyurl.com/jhusupplementsurvey The Johns Hopkins University School of Medicine is seeking volunteers to complete an online survey study about substance use. We want to learn more about experiences with novel or less commonly used substances, such as kratom, kava, akuamma seed, and tianeptine. If you have used these substances, you may be eligible to complete the …
Johns Hopkins Requesting Participation of Kratom Consumers in a New Survey Read More »
Note: We report on ongoing science. Not enough evidence has been established to conclude that kratom or mitragynine is an effective treatment for any disease. Scientists have discovered that kratom can inhibit enzymes that play a role in fat absorption. In an in vitro study, scientists found that mitragynine is a potent inhibitor of lipase, …
Kratom Shown to Inhibit Fat, Glucose Accumulation In Vitro Read More »
In a letter to the journal Addiction, kratom scientists including Oliver Grundmann, Christopher McCurdy, Abhisheak Sharma, Kirsten Smith, and Marc Swogger emphasized that kratom leaf, sold in crushed or dried for in the West and used for at least hundreds of years in Southeast Asia, is different from kratom alkaloid extract products, manufactured recently and …
Scientists: Kratom Extract “A Blessing and a Curse” Read More »
The alkaloid speciogynine may be a starting point for low-risk treatment Self-reports of kratom use as an alcohol substitute exist online, though they have not been as well documented in the scientific literature as other motivations for kratom use, such as substitution for opiates (Smith et al, 2023). In one survey of US residents, 18% …
Kratom Could Reduce Alcohol Consumption, Say Scientists Read More »
A study published in American Journal of Public Health found fatal drug overdoses increased following police seizures of illicit substances. Researchers examined data over a two year period in Marion County, Indiana, and “compared frequency and characteristics of drug (i.e., opioids and stimulants) seizures with changes in fatal overdose, emergency medical services nonfatal overdose calls …
Study Finds Drug Busts Related to Increase in Overdose Deaths Read More »
Last year, we published a 255 page document of first-person experiences that kratom consumers posted in the comments section of KratomScience.com articles. Other places like Reddit.com/r/kratom feature thousands of kratom testimonies. So far the nuances of these experiences, though abundant and similar, have not been reflected in the science. Case reports, often woefully inadequate in …
Scientists Interview Kratom Consumers About Their Experience Read More »