Mitraphylline is an oxindole alkaloid, made mostly of carbon, hydrogen, nitrogen, and oxygen. It’s found in kratom at trace amounts (less than 1% of the total alkaloid makeup of kratom leaf). Cat’s Claw contains much more of the alkaloid: 1 gram of dried cat’s claw bark might contain 0.5 to 3 milligrams of mitraphylline. Research …
Scientists Discover How Plants Make Mitraphylline Read More »
Note: There is a correlation between kratom and seizures, but causation has not been established. Kratom alone or kratom combined with other substances could very well cause seizures in some consumers, but as this study shows, there is not enough evidence to determine causation. Seizures have been commonly listed as a side effect of kratom …
Scientists find “insufficient evidence to suggest that kratom causes seizures” Read More »
Scientists from British Columbia Institute of Technology and University of Illinois published a study that examines five 7-hydroxymitragynine (the abbreviation 7-OH has become popularized, but the scientists use 7-HMG in this study) products marketed as “kratom extracts”. A kratom extract is a concentrated form of the kratom plant made by extracting its active alkaloids, of …
Scientists Test 7-OH Products Marketed as ‘Kratom Extracts’ Read More »
A new study published in Frontiers in Plant Science is presenting a clearer picture of how post-harvest processing changes the plant’s chemistry. The researchers from University of Florida and Oregon State University compared kratom varieties grown in Hawaii and Malaysia to see how factors like withering time, drying temperature, and harvest season influence alkaloid profiles—particularly …
Important to note: This does NOT mean severe health risks from kratom alone do not exist. There is a toxic amount of any substance that can be ingested, including kratom. The majority, but not all, of toxic adverse events associated with kratom have involved other substances, as well as substance misuse in general. Kratom should …
Review Finds Insufficient Evidence of Severe Health Risks From Kratom Alone Read More »
The kratom industry is railing against 7-OH products as problematic, but are extra-strength kratom extracts problematic too? The controversy surrounding the rise of new 7-hydroxymitragynine (7-OH) products has sparked a debate among various players in the kratom industry, as well as scientists and consumers. A debate called “The 7-OH Fault Line” took place at the …
Members of the American Kratom Association (AKA) and the Holistic Alternative Recovery Trust (HART) will debate the controversial alkaloid 7-hydroxymitragynine (7-OH) and the 7-OH-abundant products that have become available to consumers in the past 2 years. Billed as “The 7-OH Fault Line”, the debate will take place at the Las Vegas Convention Center 3150 Paradise …
AKA and HART Face Off Over 7-Hydroxymitragynine This Friday Read More »
Disclaimer: Kratom Is Not a Breast Cancer Treatment: While this study investigates the potential of kratom compounds mitragynine and 7-hyroxymitragynine to bind with HER2 receptors through computer modeling, it does not prove or suggest that kratom cures breast cancer. These results are preliminary and based solely on in silico simulations (i.e., computer-generated predictions). No clinical …
Preliminary in silico Study Explores Kratom Alkaloids’ Effects on Breast Cancer Protein Read More »
Thailand has announced funding for 33 new research and development projects for kratom. The National Herbal Medicines Policy Committee has listed the traditional plant as a “herb of the year” for 2025. Along with phlai and black ginger, special consideration will be given to promote kratom for export and for use in wellness centers and …
Thailand Launches 33 New Research and Development Projects for Kratom Read More »
Disclaimer: Preclinical studies on compounds’ effects on test animals do not always demonstrate exactly how compounds will affect humans A new study in rats examined the respiratory effects of mitragyinine (MG), considered the main compound in most kratom leaves consumed by users, and 7-hydroxymitragyinine (7-HMG) that occurs in very trace amounts in dried kratom leaf …