kratom

45. Dr. Abisheak Sharma, Pharmacokineticist and Kratom Researcher

Kratom Science
45. Dr. Abisheak Sharma, Pharmacokineticist and Kratom Researcher
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Dr. Abisheak Sharma studied pharmacy and pharmacokinetics in India before coming to the United States to research under kratom expert Dr. Bonnie Avery. He now researches kratom with Dr. Christopher McCurdy at University of Florida as part of the Translational Drug Development Core. Dr. Sharma addresses the concern with kratom and other drug interactions, improved …

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Levels of Kratom Alkaloid Mitragynine Were Likely Overestimated in Autopsies

A research article in the journal Drug Testing and Analysis uncovered a flaw in previous examinations of kratom’s main alkaloid, mitragynine. The study, lead by University of Florida pharmacutics researcher Dr. Abisheak Sharma, stated: There is a possibility that earlier reported studies did not separate the four mitragynine diastereomers, resulting in over‐quantification of mitragynine in …

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13. Journal Club: How Kratom Alkaloids Act on Brain Receptors

Kratom Science
13. Journal Club: How Kratom Alkaloids Act on Brain Receptors
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We all know the mitragynine and 7-hydroxymitraginine act on the mu-opioid receptor. But for episode #13 of Journal Club we talk about a study that looks closely at the binding affinity of various kratom alkaloids on the plethora of opioid and adrenergic receptors in the brain. How exactly does this work? How do different alkaloids …

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Full Text of 2018 HHS Letter to DEA Rescinding Kratom Ban Recommendation

DEPARTMENT OF HEALTH AND HUMAN SERVICESOffice of the SecretaryOffice of the Assistant Secretary for HealthWashington, D.C. 20201 AUG 16 2018 [stamped] The Honorable Uttam DhillonActing AdministratorDrug Enforcement AdministrationU.S. Department of Justice8701 Morrissette DriveSpringfield, VA 22152 Dear Mr. Dhillon: Pursuant to the Controlled Substances Act (CSA), 21 U.S.C. § 811, I am rescinding our prior recommendation …

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44. Biomedical Educator and Research Scientist Dr. Walter Prozialeck

Kratom Science
44. Biomedical Educator and Research Scientist Dr. Walter Prozialeck
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My guest is Dr. Walter Prozialeck. Originally from Johnstown, PA, Dr. Prozialeck is a biomedical educator and researcher at Midwestern University in Chicago, where he served as chair of the Department of Pharmacology from 1997 to 2018. He’s been studying kratom since 2012. We talk about one of the first research reviews published on kratom …

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Federal Research on Kratom Granted for 2021

The United States House Committee on Appropriations has allocated the Agency for Healthcare Research and Quality (AHRQ) $500,000 towards kratom research for the year of 2021. The AHRQ was given a budget of $338,000,000 in total. “The Committee is aware of the potential promise of kratom-derived compounds for acute and chronic pain patients who seek safer …

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UF Researchers First to Grow Kratom for Published Study

In one of the first formal studies of its kind, if not the very first, a team from University of Florida cultivated 68 kratom trees and fertilized them at different rates, then measured for alkaloid content, chlorophyll, and total biomass. The study, “Effects of Nutrient Fertility on Growth and Alkaloidal Content in Mitragyna speciosa (Kratom)” …

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FDA Head Ranted About Kratom on Twitter a Day After HHS Quietly Withdrew Ban Recommendation

On August 16, 2018, Brett Giroir, Assistant Secretary of Health for the Department of Health and Human Services (HHS) sent a letter to then Acting Administrator of the Drug Enforcement Administration (DEA), Uttam Dhillon, rescinding a previous HHS recommendation that kratom should be federally outlawed. Pursuant to the Controlled Substances Act…, I am rescinding our …

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Federal Actions on Kratom: 2006 to 2018 HHS Decision to Withhold Ban

This is a timeline of actions taken by federal agencies concerning kratom up to the August 16, 2018 HHS decision to withdraw a recommendation to ban kratom. FDA has been the most active federal agency in trying to control kratom, from releasing several import alerts, to requesting shipment seizures, to sending cease and desist letters …

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American Kratom Assn: FDA sat on a letter from HHS reversing kratom ban recommendation in 2018

Previously unreleased HHS letter discovered according to AKA Press Release Via the American Kratom Association (AKA) press conference held today, the Department of Health and Human Services had withdrawn its recommendation back in 2018 to the Drug Enforcement Administration that kratom become a Schedule 1 Drug. The HHS initially recommended kratom be put on Schedule …

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