kratom science

Study: Mitragynine/Naltrexone Combo Reduces Alcohol Use in Rats

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Disclaimer:Research findings from animal studies do not always translate directly to humans. Differences in biology, metabolism, and dosing mean that results observed in animals may not reflect the same effects or safety in people. Animal research is an early step in understanding how a substance might work, but human clinical studies are necessary to determine …

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FDA Study on Kratom Published

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A long-awaited kratom clinical study conducted by the U.S. Food and Drug Administration (FDA) has been published in the Journal of Clinical Psychopharmacology. The pilot study (defined as “a preliminary investigation designed to test the feasibility and design of a larger, more comprehensive study”) involved healthy adult participants who were administered an ascending dose of …

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Is 7-OH Really “13 times stronger than morphine”?

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Multiple news media and even medical professionals have repeated the claim that 7-hydroxymitragynine (7-OH) is “13 times stronger than morphine” as though it is a fact established through rigorous science. Where does this claim come from and how accurate is it? The claim comes from studies from 2002 (Takayama, et al) and 2004 (Matsumoto, et …

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Fifth Scientific Kratom Symposium Held in Florida

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The Director of the National Institute on Drug Abuse (NIDA), Nora Volkow, was the keynote speaker for this year’s Scientific Kratom Symposium. Hosted by the University of Florida College of Pharmacy at its Lake Nona research campus, the four-day event held from February 17-20, 2026, brought together roughly 100 scientists from about a dozen countries …

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Tupelo Convenience Store Owner Appeals Kratom Ban

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Mohamed Gamiel, owner of Sarah Quick Stop and Liquor Corner Store in Tupelo, MS, has filed an appeal of the town’s recent decision to ban the manufacture, sale, and possession of kratom. The appeal was filed last week in Lee County Circuit Court. Gamiel argues in his appeal that Tupelo’s kratom ban is arbitrary, unsupported …

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Kratom Use Disorder Treatment with Methadone an Ongoing Practice

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A case series published recently in the Journal of Addiction examined 14 American patients of Community Medical Services, a healthcare company specializing in the medically assisted treatment of Opioid Use Disorder (OUD). The patients were diagnosed with Kratom Use Disorder (KUD) (Sherrick, 2026). The very brief report does not get into specifics about kratom product …

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Study: Traditional Kratom Use Not Associated with Blood, Organ Toxicity

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Disclaimer This is an article summarizing a study on kratom consumers from Thailand, who use the traditional method of fresh leaf kratom brewed into a tea. This is not how most people consume kratom in the United States and Europe. Though the alkaloid composition varies from fresh to dried leaf kratom, the closest method to …

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Scientists Discover How Plants Make Mitraphylline

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Mitraphylline is an oxindole alkaloid, made mostly of carbon, hydrogen, nitrogen, and oxygen. It’s found in kratom at trace amounts (less than 1% of the total alkaloid makeup of kratom leaf). Cat’s Claw contains much more of the alkaloid: 1 gram of dried cat’s claw bark might contain 0.5 to 3 milligrams of mitraphylline. Research …

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Scientists find “insufficient evidence to suggest that kratom causes seizures”

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Note: There is a correlation between kratom and seizures, but causation has not been established. Kratom alone or kratom combined with other substances could very well cause seizures in some consumers, but as this study shows, there is not enough evidence to determine causation. Seizures have been commonly listed as a side effect of kratom …

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Study: Kratom alkaloid make-up dependent on genetics, environmental factors, and processing

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A new study published in Frontiers in Plant Science is presenting a clearer picture of how post-harvest processing changes the plant’s chemistry. The researchers from University of Florida and Oregon State University compared kratom varieties grown in Hawaii and Malaysia to see how factors like withering time, drying temperature, and harvest season influence alkaloid profiles—particularly …

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