kratom research

Scientists find “insufficient evidence to suggest that kratom causes seizures”

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Note: There is a correlation between kratom and seizures, but causation has not been established. Kratom alone or kratom combined with other substances could very well cause seizures in some consumers, but as this study shows, there is not enough evidence to determine causation. Seizures have been commonly listed as a side effect of kratom …

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Scientists Test 7-OH Products Marketed as ‘Kratom Extracts’

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Scientists from British Columbia Institute of Technology and University of Illinois published a study that examines five 7-hydroxymitragynine (the abbreviation 7-OH has become popularized, but the scientists use 7-HMG in this study) products marketed as “kratom extracts”. A kratom extract is a concentrated form of the kratom plant made by extracting its active alkaloids, of …

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Study: Kratom alkaloid make-up dependent on genetics, environmental factors, and processing

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A new study published in Frontiers in Plant Science is presenting a clearer picture of how post-harvest processing changes the plant’s chemistry. The researchers from University of Florida and Oregon State University compared kratom varieties grown in Hawaii and Malaysia to see how factors like withering time, drying temperature, and harvest season influence alkaloid profiles—particularly …

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Review Finds Insufficient Evidence of Severe Health Risks From Kratom Alone

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Important to note: This does NOT mean severe health risks from kratom alone do not exist. There is a toxic amount of any substance that can be ingested, including kratom. The majority, but not all, of toxic adverse events associated with kratom have involved other substances, as well as substance misuse in general. Kratom should …

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Study: Mitragynine Stimulated and 7-Hydroxymitragynine Depressed Respiratory Activity in Rats

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Disclaimer: Preclinical studies on compounds’ effects on test animals do not always demonstrate exactly how compounds will affect humans A new study in rats examined the respiratory effects of mitragyinine (MG), considered the main compound in most kratom leaves consumed by users, and 7-hydroxymitragyinine (7-HMG) that occurs in very trace amounts in dried kratom leaf …

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Study Shows Kratom Leaves Attacked by Insects Have Higher Mitragynine

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Read the full study, where the above image can be found: https://pmc.ncbi.nlm.nih.gov/articles/PMC12040156 Researchers at Kasetsart University and Chulalongkorn University in Bangkok, Thailand found that when insects like beetles, butterflies, and true bugs feed on kratom, the plant produces more mitragynine as a defense mechanism. This increase is also linked to higher leaf acidity. Plants produce …

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Federal Research on Kratom Granted for 2021

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The United States House Committee on Appropriations has allocated the Agency for Healthcare Research and Quality (AHRQ) $500,000 towards kratom research for the year of 2021. The AHRQ was given a budget of $338,000,000 in total. “The Committee is aware of the potential promise of kratom-derived compounds for acute and chronic pain patients who seek safer …

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Why the AHRQ Review On Chronic Pain Matters

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December 2020 The Agency for Healthcare and Research Quality (AHRQ) is currently conducting a systematic review on plant-based treatment for chronic pain. Their goal: “identify alternative treatments (to opioids) with equal or better benefits for pain while avoiding potential unintended consequences.” Specifically, they will be reviewing the benefits and potential harms of cannabinoids and kratom. …

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Leading Kratom Scientists Call on FDA, DEA to Keep Kratom Legal

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In a recent article published in International Journal of Drug Policy, leading kratom researchers called on the FDA, DEA, and legislators to keep kratom legal, as placing kratom on Schedule 1 would impede research and cause damaging public health consequences. Authors included Chris McCurdy, Andrew Kruegal, Jack Henningfield, and the late Bonnie Avery (who passed …

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