7-hydroxymitragynine

Ohio Introduces Kratom Regulation Bill After Governor Called for Ban in August

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Senator Louis Blessing introduced a bill in the Ohio Senate that will regulate rather than ban kratom. Introduced on October 21, SB299 would limit the amount of naturally-occurring 7-hydroxymitragynine (7-OH) to less than 2% of alkaloids or 1 milligram per serving. All synthetic or semi-synthetic alkaloids will be made illegal to sell. Each product must …

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Scientists find “insufficient evidence to suggest that kratom causes seizures”

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Note: There is a correlation between kratom and seizures, but causation has not been established. Kratom alone or kratom combined with other substances could very well cause seizures in some consumers, but as this study shows, there is not enough evidence to determine causation. Seizures have been commonly listed as a side effect of kratom …

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Scientists Test 7-OH Products Marketed as ‘Kratom Extracts’

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Scientists from British Columbia Institute of Technology and University of Illinois published a study that examines five 7-hydroxymitragynine (the abbreviation 7-OH has become popularized, but the scientists use 7-HMG in this study) products marketed as “kratom extracts”. A kratom extract is a concentrated form of the kratom plant made by extracting its active alkaloids, of …

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California Dept of Public Health Seizes Kratom Despite Lack of Prohibition Laws

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Last week, the California Department of Public Health (CDPH) announced it has seized $5 million worth of kratom and 7-hydroxymitragynine (7-OH) products, despite no law explicitly prohibiting kratom and 7-OH in the state. Grant Boyken of CDPH told SFGATE the products were placed under embargo “pending further regulatory actions”. Boyken cited California’s Sherman Food, Drug, …

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Study: Kratom alkaloid make-up dependent on genetics, environmental factors, and processing

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A new study published in Frontiers in Plant Science is presenting a clearer picture of how post-harvest processing changes the plant’s chemistry. The researchers from University of Florida and Oregon State University compared kratom varieties grown in Hawaii and Malaysia to see how factors like withering time, drying temperature, and harvest season influence alkaloid profiles—particularly …

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Could Kratom Consumers Catch DUI if 7-OH is Banned?

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The alkaloid 7-hydroxymitragynine (7-OH) is unique in that it occurs mostly as a metabolite of mitragynine (MG), the most abundant alkaloid in kratom. On July 29, the Food and Drug Administration (FDA) announced its intention to recommend scheduling of 7-OH on the list of federally controlled substances, but explicitly stated that its not going after …

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Wave of Negative News Engulfs Kratom Since FDA Move to Schedule 7-OH

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A wave of negative media coverage (more than usual) has engulfed kratom in the weeks following the FDA’s July 29 recommendation to classify 7-hydroxymitragynine (7-OH) as an illicit substance. While the agency’s move targets products containing an abundance of 7-OH—not the plain leaf kratom that contains near-zero amounts of 7-OH—news outlets have blurred the distinction, …

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Dr. McCurdy at Kratom Debate: Natural Leaf is “the only product that should be in the marketplace”

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The kratom industry is railing against 7-OH products as problematic, but are extra-strength kratom extracts problematic too? The controversy surrounding the rise of new 7-hydroxymitragynine (7-OH) products has sparked a debate among various players in the kratom industry, as well as scientists and consumers. A debate called “The 7-OH Fault Line” took place at the …

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AKA and HART Face Off Over 7-Hydroxymitragynine This Friday

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Members of the American Kratom Association (AKA) and the Holistic Alternative Recovery Trust (HART) will debate the controversial alkaloid 7-hydroxymitragynine (7-OH) and the 7-OH-abundant products that have become available to consumers in the past 2 years. Billed as “The 7-OH Fault Line”, the debate will take place at the Las Vegas Convention Center 3150 Paradise …

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Isolated 7-hydroxymitragynine Now Being Sold in Tablets and Liquid Shots

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Companies are now selling isolated 7-hydroxymitragyinine in a grey marketplace that the Food and Drug Administration (FDA) refuses to regulate. Found in near-zero amounts in plain leaf kratom, 7-hydroxymitragyinine has been shown in animal studies to have enormous dependency potential. Obeng et al 2020 demonstrated that while mitragynine, kratom’s most abundant alkaloid, has “a complex …

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