Study: Mitragynine/Naltrexone Combo Reduces Alcohol Use in Rats

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Disclaimer:Research findings from animal studies do not always translate directly to humans. Differences in biology, metabolism, and dosing mean that results observed in animals may not reflect the same effects or safety in people. Animal research is an early step in understanding how a substance might work, but human clinical studies are necessary to determine …

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Bill in Kentucky Seeks to Create “Department of Psychoactive Substances”

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Kentucky Representative Alan Gentry, a Democrat from Louisville representing District 46, has introduced HB895, a bill that would create a “Department of Psychoactive Substances” that will regulate legal psychoactives like kratom and hemp byproducts. Kentucky’s HB895 shares a nearly identical regulatory philosophy with Czech Republic’s Psychomodulatory Substances program (primarily established through the Psychomodulatory Substances Act …

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Czech Prime Minister Threatens Kratom Ban Months After New Regulations

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Kratom Science has been following a lengthy political process that has taken place to regulate kratom in the Czech Republic since 2022, when groups such as the European Kratom Alliance (EKA), the Czecho-Slovak Kratom Association (CSKA), and the Pirate Party began to push for such regulation. The Czech Republic’s progressive National Drug Policy Coordinator, Jindrich …

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FDA Study on Kratom Published

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A long-awaited kratom clinical study conducted by the U.S. Food and Drug Administration (FDA) has been published in the Journal of Clinical Psychopharmacology. The pilot study (defined as “a preliminary investigation designed to test the feasibility and design of a larger, more comprehensive study”) involved healthy adult participants who were administered an ascending dose of …

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Kansas Authorities Seize Kratom Shots Containing Alcohol

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The Alcoholic Beverage Control Division (ABC), an agency within the Kansas Department of Revenue (KDOR), seized 1,006 OPMS liquid kratom extract products from 12 businesses that ABC claims contain 15.7% to 16.1% ethanol. Ethanol (the type of alcohol also found in alcoholic beverages) is used to extract alkaloids from kratom leaf to produce highly concentrated …

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Is 7-OH Really “13 times stronger than morphine”?

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Multiple news media and even medical professionals have repeated the claim that 7-hydroxymitragynine (7-OH) is “13 times stronger than morphine” as though it is a fact established through rigorous science. Where does this claim come from and how accurate is it? The claim comes from studies from 2002 (Takayama, et al) and 2004 (Matsumoto, et …

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Local Governments Crack Down on Kratom as 2026 Bans Expand

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UPDATED April 10, 2026: Multiple towns added Several American towns, cities, and counties have moved to ban the sale and distribution of kratom since the beginning of 2026. Some jurisdictions in Illinois and Mississippi moved to both ban sale and possession, criminalizing kratom consumers. This comes after last year’s announcement by the Food and Drug …

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Conflicting Signals: Georgia HB 968 Makes Kratom’s Active Compounds Illegal While Regulating Its Sale

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Georgia House Bill 968 contains language that would add kratom compounds to the list of Schedule I controlled substances, and at the same time restrict the sale of kratom to over-the-counter sales in pharmacies. One problem with this bill: It is legally impossible. Under HB 968, the pharmacy sales provision for kratom is designed to allow …

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Gavin Newsom calls kratom and 7-OH “illicit and deadly”

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Though no prohibition law has passed, California Governor Gavin Newsom is voicing support for the unilateral decision by his California Department of Public Health (CDPH) to declare kratom and 7-OH products illegal and confiscate them from retail shops across the state. Gov. Newsom tweeted this on Tuesday: I will not stand by while dangerous, illegal …

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