Research

Preliminary in silico Study Explores Kratom Alkaloids’ Effects on Breast Cancer Protein

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Disclaimer: Kratom Is Not a Breast Cancer Treatment: While this study investigates the potential of kratom compounds mitragynine and 7-hyroxymitragynine to bind with HER2 receptors through computer modeling, it does not prove or suggest that kratom cures breast cancer. These results are preliminary and based solely on in silico simulations (i.e., computer-generated predictions). No clinical …

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Thailand Launches 33 New Research and Development Projects for Kratom

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Thailand has announced funding for 33 new research and development projects for kratom. The National Herbal Medicines Policy Committee has listed the traditional plant as a “herb of the year” for 2025. Along with phlai and black ginger, special consideration will be given to promote kratom for export and for use in wellness centers and …

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Study: Mitragynine Stimulated and 7-Hydroxymitragynine Depressed Respiratory Activity in Rats

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Disclaimer: Preclinical studies on compounds’ effects on test animals do not always demonstrate exactly how compounds will affect humans A new study in rats examined the respiratory effects of mitragyinine (MG), considered the main compound in most kratom leaves consumed by users, and 7-hydroxymitragyinine (7-HMG) that occurs in very trace amounts in dried kratom leaf …

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Nefarious Marketing: Making Health Claims and Synthetics Sold as “Kratom”

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Health Claims in Texas Smoke Shops With a dearth of regulation and market enforcement, marketers of kratom, kratom-derived synthetics, and products like hemp and THC continue to employ shady business practices to sell their products. Researchers from university pharmacy and medicine departments conducted a secret shopper investigation at 100 smoke shops in San Antonio and …

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Study Shows Kratom Leaves Attacked by Insects Have Higher Mitragynine

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Read the full study, where the above image can be found: https://pmc.ncbi.nlm.nih.gov/articles/PMC12040156 Researchers at Kasetsart University and Chulalongkorn University in Bangkok, Thailand found that when insects like beetles, butterflies, and true bugs feed on kratom, the plant produces more mitragynine as a defense mechanism. This increase is also linked to higher leaf acidity. Plants produce …

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Johns Hopkins Seeks Participants for Online Study on 7-OH Kratom Products

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The Johns Hopkins University School of Medicine is conducting a groundbreaking online study on 7-hydroxymitragynine (7-OH), a compound associated with certain kratom products. The study invites individuals who have consumed 7-OH products to participate by completing a screening process and, if eligible, an online survey about their usage patterns. As a thank-you, participants who complete …

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Johns Hopkins Requesting Participation of Kratom Consumers in a New Survey

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tinyurl.com/jhusupplementsurvey The Johns Hopkins University School of Medicine is seeking volunteers to complete an online survey study about substance use. We want to learn more about experiences with novel or less commonly used substances, such as kratom, kava, akuamma seed, and tianeptine. If you have used these substances, you may be eligible to complete the …

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Kratom Shown to Inhibit Fat, Glucose Accumulation In Vitro

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Note: We report on ongoing science. Not enough evidence has been established to conclude that kratom or mitragynine is an effective treatment for any disease. Scientists have discovered that kratom can inhibit enzymes that play a role in fat absorption. In an in vitro study, scientists found that mitragynine is a potent inhibitor of lipase, …

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Scientists: Kratom Extract “A Blessing and a Curse”

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In a letter to the journal Addiction, kratom scientists including Oliver Grundmann, Christopher McCurdy, Abhisheak Sharma, Kirsten Smith, and Marc Swogger emphasized that kratom leaf, sold in crushed or dried for in the West and used for at least hundreds of years in Southeast Asia, is different from kratom alkaloid extract products, manufactured recently and …

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Kratom Could Reduce Alcohol Consumption, Say Scientists

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The alkaloid speciogynine may be a starting point for low-risk treatment Self-reports of kratom use as an alcohol substitute exist online, though they have not been as well documented in the scientific literature as other motivations for kratom use, such as substitution for opiates (Smith et al, 2023). In one survey of US residents, 18% …

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