Study shows mitragynine metabolizes into 7-Hydroxomitragynine
Illustration from Kruegel study of MG being metabolized into 7OH before acting on the MOR to produce pain relieving effects

Study shows mitragynine metabolizes into 7-Hydroxomitragynine

Citation Kruegel AC, Uprety R, Grinnell SG, et al. 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects. ACS Cent Sci. 2019;5(6):992-1001. doi:10.1021/acscentsci.9b00141 Summary…

Continue Reading Study shows mitragynine metabolizes into 7-Hydroxomitragynine
Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine
photo by riccardo ragione, downloaded from usplash

Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine

Article Citation with Link to Full Text Harun N, Johari IS, Mansor SM, Shoaib M. Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats. Psychopharmacology (Berl).…

Continue Reading Study: Pure mitragynine “does not induce physiological dependence” in rats, treated morphine withdrawal more efficiently than buprenorphine